Skip to main content

Advertisement

Table 1 Patient characteristics before and after dexamethasone 4 mg/day for 4 days

From: Evidence for transcript-specific epigenetic regulation of glucocorticoid-stimulated skeletal muscle 11β-hydroxysteroid dehydrogenase-1 activity in type 2 diabetes

Characteristic Pre dexamethasone Post dexamethasone
Fasting glucose (mmol/l) 7.0 (6.1 to 9.8) 7.6 (6.4 to 12.9)a
Fasting insulin (mU/l) 13.1 (9.6 to 15.5) 15.8 (11.4 to 17.8)a
HOMA2-IR 2.0 (1.3 to 2.1) 2.4 (1.6 to 2.9)b
11βHSD1 mRNA (relative expression) 3.06 (1.81 to 4.61) 3.06 (2.70 to 6.11)b
11βHSD1 oxoreductase activity (% conversion) 11.3 (4.7 to 17.4) 15.5 (11.6 to 19.3)a
C/EBPβ mRNA (relative expression) 1.37 (0.32 to 2.46) 2.06 (0.85 to 3.11) a
P1 promoter mRNA (relative expression, n = 11) 0.03 (0.02 to 0.04) 0.06 (0.03 to 0.22)b
P2 promoter mRNA (relative expression, n = 11) 0.83 (0.63 to 1.13) 1.40 (0.77 to 1.78)a
  1. Data presented as median (25th to 75th percentile). The Wilcoxon signed-rank test examined the significance of the median difference between paired values. 11βHSD1, 11β-hydroxysteroid dehydrogenase-1; C/EBP, CCAAT/enhancer-binding protein; HOMA, homeostasis model assessment. P <0.05 compared with pre dexamethasonea. P < 0.01compared with pre dexamethasoneb.