Sirtuin1 single nucleotide polymorphism (A2191G) is a diagnostic marker for vibration-induced white finger disease

Table 2 Overview of the potential nonsynonymous Sirt1 SNPsin silico and analyzed

dbSNP [Assay ID]	Region	5^′Near Seq 30 bp	Allele	3^′Near Seq 30 bp	Codon position	Protein residue	Amino acid position
rs1063114	Exon 8	agactgtgatgtcataattaatgaattgtg	A/T	cataggttaggtggtgaatatgccaaactt	3	*Ter/Cys [/C]**	490
[C_9638456_10]	Exon 8	agactgtgatgtcataattaatgaattgtg	ancestral allele: T	cataggttaggtggtgaatatgccaaactt	3	*Ter/Cys [/C]**	490
rs1063111	Exon 8	ttgatgtagagcttcttggagactgtgatg	A/T	cataattaatgaattgtgtcataggttagg	2	Asp/Val [D/V]	484
[C_9638445_10]	Exon 8	ttgatgtagagcttcttggagactgtgatg	ancestral allele: T	cataattaatgaattgtgtcataggttagg	2	Asp/Val [D/V]	484
rs1063112	Exon 8	atgtagagcttcttggagactgtgatgtca	C/T	aattaatgaattgtgtcataggttaggtgg	2	Thr/Ile	485
[SIRT1-A485]	Exon 8	atgtagagcttcttggagactgtgatgtca	ancestral allele: T	aattaatgaattgtgtcataggttaggtgg	2	[T/I]	485
rs35224060	Exon 9	ggagatgatcaagaggcaattaatgaagct	A/G	tatctgtgaaacaggaagtaacagacatga	1	Ile/Val	731
[C_25611590_10]	Exon 9	ggagatgatcaagaggcaattaatgaagct	ancestral allele: n.a.	tatctgtgaaacaggaagtaacagacatga	1	[I/V]	731
rs3740051	promoter	agccgcctccttttgcctctcttcctactt	A/G	ttaacaaaacagaacgactatccaacgtat	-	-	-
[C_27471644_10]			A/G
[C_27471644_10]			ancestral allele: A
rs2236319	Intron 4	agggatgtcagtctgatggagaaattgggt	A/G	tttgttagatctttatgagaaactggaaac	-	-	-
[C_15954063_10]			ancestral allele: A

ISSN: 1868-7083