Epigenetic dysregulation of secreted frizzled-related proteins in myeloproliferative neoplasms complements the JAK2V617F-mutation

Table 1 Characteristics of the patient cohort

	JAK2		Age	Gender		WBC (10⁹/L)	Hb (g/L)	Plt (10⁹/L)	Blasts (%)	LDH (U/L)
	mut	wt		m	f
CML (n = 10)	0	10	55	9	1	81.3	107	219	1	599
PV (n = 10)	8	2	56	4	6	12.4	133	370	0	259
ET (n = 10)	5	5	69	3	7	8.2	130,5	770	0	267
MF (n = 27)	14	13	67	12	15	10.1	104,5	376	0,5	431
Total	27	30	66	28	29	11.7	114	338	0	369

Median values for age, WBC, Hb, Plt, Blasts, LDH. CML, Chronic myeloid leukemia, ET, essential thrombocythemia; Hb, hemoglobin; LDH, lactate dehydrogenase; MF, myelofibrosis; mut, positive for JAK2V617F; plt, platelet count; PV, polycythemiavera; WBC, white blood cell count; wt = negative for JAK2V617F.

ISSN: 1868-7083