From: Suffocating cancer: hypoxia-associated epimutations as targets for cancer therapy
 | Modification observed in hypoxia related tumourigenesis | Therapeutic potential |
---|---|---|
DNA methylation | Global DNA hypomethylation | • DNMT inhibition in haematological malignancies • Re-expression of specific tumour suppressor genes (eg. VHL) through decitabine therapy |
Histone modification | • Hypoxic regulation of histone demethylase activity • Up-regulation of HDAC1 and histone methyltransferase | • HDAC inhibitors disrupt HIF through altered transcription and degradation • Combination of HDAC inhibiton with mTOR inhibition has additive effect in vitro |
miRNAs | mi-RNAs associated with diagnosis and prognosis eg mi-210 | • Selected hypoxia related mi-RNA inhibition through - Anti-miRNA oligonucleotides - Antagomirs • Indirect regulation of miRNA through HIF inhibitors |