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Table 1 Relationship between APC promptor methylation and clinicopathology parameters in healthy controls and cases.

From: Analysis of hypermethylation and expression profiles of APC and ATM genes in patients with oral squamous cell carcinoma

Characteristics

Controls

* APC Methylation status

P value

Cases

APC methylation status

**P

value

 

N = 57

 

N=84

     
  

Present

N (%)

Absent

N (%)

  

Present

N (%)

Absent

N (%)

 

Mean age

39.07 ± 14

   

54.14 ± 18

   

< 50

46

39 (84.8)

7 (15.2)

 

26

20(76.93)

6 (23.07)

 
    

0.9

   

0.2

> 50

11

10(90.90)

1 (9.1)

 

58

39(67.24)

19(32.76)

 

Sex

        

Male

21

18 (85.7)

3 (14.3)

 

39

32(82.05)

7 (17.95)

 
    

0.06

   

0.72

Female

36

32(88.88)

4 (11.12)

 

45

28(62.22)

17(37.78)

 

Stage

       

0.05

I

-

-

-

-

18

11(61.11)

7(38.89)

 

II

    

18

15(83.33)

3(16.64)

 

III

    

43

31(72.08)

12(27.92)

 

IV

    

5

2(40)

3(60)

 
  1. * Methylation present: means that PCR product is produced only with methylated primers.
  2. Methylation absent: means that PCR product is produced only with unmethylated primers.
  3. **Chi-square test