Figure 4

Epigenetic regulators of neurogenesis on the development of pathological behavioural traits. Several epigenetic regulators have been implicated in the control of the adult neurogenic process. As such, it is likely that the mechanistic action of these molecules is implicated in the behavioural dimensions commonly affected in depression: Mood (M), Anxiety (A) and Cognition (C). "✓" indicates that such involvement has been described; "?" indicates that the implications of the molecule are unknown or still unclear. a PcG and TrxG protein complexes silence or activate, respectively, the transcription of target genes and have been implicated in the control of the neurogenic process; however, repercussions at the behavioural level still remain to be described; b MBD1 action is associated with the histone-lysine N-methyltransferase SETDB1, silencing target genes; notably, deficits in this molecule has been associated to deficits in all three behavioural dimension of depression. c DNMTs participate in the regulation of a broad range of neurogenesis processes, being its action strongly related to deficits in learning and memory; although some studies suggest that they might be also involved in the transcriptional regulation of pathways associated to mood and anxiety, such correlation needs to be further endorsed; d MeCP2 integrates a major chromatin silencing complex comprising several others epigenetic regulators, such as HDAC1, involved in the trancriptional regulation of several genes. Deficits in this molecule have been correlated with cognitive and anxiety deficits, although no deficits in mood have been consistently described; e The REST/CoREST chromatin remodeling complex has been proposed as a major orchestrator of the action of several epigenetic regulators, such as HDAC 1 and 2, MeCP2 and the histone methyltransferase K4. Impairments in mood an cognition have been associated with REST and its molecular partners, although no implication have been described relating this molecule to anxiety