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Table 1 HDACs implicated in chromatin structure/function during DNA damage and repair

From: Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells

HDAC Role in DNA damage/repair Substrates involved in DNA damage response References
Class I    
HDAC1 Protects from DNA damage, sustains DNA damage checkpoint, maintains DNA replication, regulates oxidative stress and NHEJ H3K56, p21, p53, BRCA1, CHES1, PCNA, Top II, ATM, ATR, RFC, ING1a, APE1/Ref1 [41, 6471, 321]
HDAC2 Participates in DNA damage signaling by translocation to nucleus; regulates DNA repair H3K56, BRCA1, ATR [41, 66, 68]
HDAC3 Protects from DNA damage, maintains replication fork, mitotic spindle and helps in DNA repair and genomic stability via HDAC3/NCOR/SMRT complexes H3K9/K14, H4K5/K12 [42, 72, 7577]
Class IIa    
HDAC4 Increases DNA repair by translocation to the nucleus and signaling repair 53BP1 [78, 79]
HDAC9 DNA repair through homologous recombination Not yet identified [43]
Class IIb    
HDAC6 Role in chemosensitization GADD153 [80]
HDAC10 DNA repair through homologous recombination Not yet identified [43]
Class III    
SIRT1 Protects from oxidative DNA damage, maintains telomere length and activates DNA repair through HR, NER, and BER p53, FoXO1, WRN, Ku70, Tip60, APE1, H3K56, NBS1, MRN, telomere, XPA, XPC [8183, 8694, 97, 98]
SIRT3 Transports to mitochondria and reduces oxidative DNA damage Idh2, H4K16 [99, 100]
SIRT6 Promotes DNA repair by HR, forms a complex with DNA-PK and resists DNA damage; maintains chromatin structure and genomic stability H3K9/K56, CtIP, XPA, DNAPK [21, 101, 102]
  1. Information regarding HDAC 5, 7, 8 and 11 is currently lacking in terms of a definite role in this mechanism.