Figure 1
From: Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells
Model of DNA damage signaling, histone acetylation and chromatin remodeling. Recognition and signaling of a DSB is followed by opening of chromatin to repair the break, terminating in chromatin restoration after DNA break repair. HDAC inhibition, as indicated by HDACI, has been shown to affect key steps in this process (as illustrated) by virtue of deacetylating histone and non-histone proteins involved in signaling and repair.