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Table 4 Linear regression analysis: DNA methylation at IGF2 and H19 DMRs in the offspring in relation to maternal depression and the use of antidepressants, in African American and in Caucasian participants

From: The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring

  IGF2 DMR H19 DMR
  Caucasian
n 1 = 159
African American n 1 = 172 Caucasian
n 1 = 168
African American n 1 = 177
  β SE p β SE p β SE p Β SE p
Model 12:
Antidepressant use
-1.41 1.27 0.27 +1.63 2.58 0.53 -2.04 1.67 0.22 +6.89 2.53 0.01
Model 22:
Depression
+1.10 1.26 0.38 +0.29 1.69 0.86 +0.15 1.70 0.93 +0.07 1.89 0.97
  1. 1 Number of observations in the statistical analysis.
  2. 2 At IGF2 DMR: adjusted for age, education, and smoking during pregnancy.
  3. 2 At H19 DMR: adjusted for age, smoking during pregnancy, marital status, education, BMI, and birth weight.