The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring

Table 3 Multiple linear regression analyses: DNA methylation at IGF2 and H19 DMR in the offspring in relation to the use of antidepressants, depression, and race of the mother

	*IGF2* DMR n max.¹ = 356			*H19* DMR n max. ¹ = 411
	β	SE	p	β	SE	p
Model 1²: Antidepressant use	-0.47	1.28	0.71	+0.54	1.40	0.70
Model 2²: Depression	+0.72	1.06	0.50	+0.25	1.25	0.84
Model 3 ² , interaction with race: Antidepressant use Race (being African American) Antidepressants × Race (African American)	-1.63 +0.40 +3.58	1.55 0.92 2.71	0.29 0.66 0.19	-2.38 -0.01 +9.18	1.67 1.17 2.95	0.16 0.99 0.002

¹ Number included in the statistical analyses, this may vary slightly by missing variables in the different models.
² At IGF2 DMR: adjusted for age, race, education, and smoking during pregnancy.
² At H19 DMR: adjusted for age, race, smoking during pregnancy, marital status, education, BMI, and birth weight.

ISSN: 1868-7083