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Table 2 DNA methylation at IGF2 DMR and H19 DMR sites by socio-demographic characteristics

From: The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring

  

IGF2 DMR mean methylation% n = 356 (SD)

Δ (p-value)

H19 DMR mean methylation% n = 411 (SD)

Δ (p-value)

Total:

 

47.45 (6.89)

 

60.09 (7.89)

 

Maternal age:

< 30

47.43 (7.29)

+0.05 (0.95)

60.01 (7.44)

+0.18 (0.81)

 

≥30

47.48 (6.40)

 

60.19 (8.42)

 

Marital status:

living with partner

47.10 (6.59)

+0.97 (0.20)

59.48 (7.59)

+1.63 (0.05)

 

single

48.07 (7.37)

 

61.11 (8.30)

 

Race1:

African American

47.62 (7.96)

-0.52 (0.49)

61.00 (7.90)

-1.80 (0.03)

 

Caucasian

47.10 (5.60)

 

59.20 (7.60)

 

College graduate:

no

47.72 (7.04)

-0.73 (0.34)

60.73 (8.07)

-1.83 (0.03)

 

yes

46.99 (6.61)

 

58.90 (7.45)

 

Antidepressant use:

no

47.44 (7.06)

+0.17 (0.85)

60.12 (7.63)

-0.25 (0.87)

 

yes

47.61 (5.07)

 

59.87 (9.98)

 

Depression:

no

47.21 (6.65)

+1.52 (0.13)

60.18 (8.00)

-0.07 (0.95)

 

yes

48.74 (8.00)

 

60.11 (7.64)

 

BMI:

≤ 30

47.81 (7.10)

-0.71 (0.41)

59.51 (7.33)

+1.81 (0.07)

 

> 30

47.10 (7.01)

 

61.32 (9.02)

 

Smoking 1 year

non-smoker

47.69 (7.15)

-0.94 (0.24)

60.24 (7.90)

-0.53 (0.54)

before pregnancy:

smoker

46.75 (6.25)

 

59.71 (7.00)

 

Smoking during

non-smoker

46.82 (5.84)

+3.05 (0.01)

60.07 (7.83)

+0.14 (0.88)

pregnancy:

smoker

49.87 (9.62)

 

60.22 (8.22)

 

Birth weight:

< 2500 g

47.57 (8.24)

-0.14 (0.91)

58.96 (5.32)

+1.34 (0.15)

 

≥2500 g

47.43 (6.67)

 

60.30 (7.58)

 

Gender of newborn:

male

47.05 (5.86)

+0.80 (0.28)

59.67 (7.93)

+0.85 (0.28)

 

female

47.85 (6.63)

 

60.52 (7.95)

 
  1. 1 Only the data from children born to Caucasian and African American women are included; numbers of other races were too low.