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Table 1 List of genes in which expression can be altered by epigenetic mechanisms in MPNs

From: Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies

Gene Abbreviation MPN subtype Reference
Calcitonin A CALCA ET, PV, PMF Ihalainen et al. (1994)
V-abl Abelson murine leukemia viral oncogene homolog 1 ABL1 ET, PV, PMF Aviram et al. (2003)
Cyclin-dependent kinase inhibitor 2A p14 ARF CML Nagy et al. (2003); Kumagai et al. (2005); Jost et al. (2007)
p16INK4a CML
Cyclin-dependent kinase inhibitor 2b p15INK4b MF-BP Wang et al. (2002)
Secreted Frizzled-related protein 1 SFRP1 CML Bennemann et al. (2010); Pehlivan et al. (2009)
Secreted Frizzled-related protein 2 SFRP2 ET, PV, PMF Bennemann et al. (2010)
Wnt inhibitory factor-1 WIF-1 ET, PV, PMF Suzuki et al. (2007)
Suppressor of cytokine signaling 1 SOCS1 ET, PV, PMF, MF-BP Jost et al. (2007); Capello et al. (2008)
Suppressor of cytokine signaling 3 SOCS3 PMF Fernandez-Mercado et al. (2008); Fourouclas et al. (2008)
Polycythemia rubra vera protein 1 PRV1 ET, PV Jelinek et al. (2007)
C-X-C chemokine receptor type 4 CXCR4 PMF Bogani et al. (2008)
Retinoic acid receptor beta 2 RARβ2* PMF Jones et al. (2004); Jost et al. (2007)