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Table 1 List of genes in which expression can be altered by epigenetic mechanisms in MPNs

From: Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies

Gene

Abbreviation

MPN subtype

Reference

Calcitonin A

CALCA

ET, PV, PMF

Ihalainen et al. (1994)

V-abl Abelson murine leukemia viral oncogene homolog 1

ABL1

ET, PV, PMF

Aviram et al. (2003)

Cyclin-dependent kinase inhibitor 2A

p14 ARF

CML

Nagy et al. (2003); Kumagai et al. (2005); Jost et al. (2007)

p16INK4a

CML

Cyclin-dependent kinase inhibitor 2b

p15INK4b

MF-BP

Wang et al. (2002)

Secreted Frizzled-related protein 1

SFRP1

CML

Bennemann et al. (2010); Pehlivan et al. (2009)

Secreted Frizzled-related protein 2

SFRP2

ET, PV, PMF

Bennemann et al. (2010)

Wnt inhibitory factor-1

WIF-1

ET, PV, PMF

Suzuki et al. (2007)

Suppressor of cytokine signaling 1

SOCS1

ET, PV, PMF, MF-BP

Jost et al. (2007); Capello et al. (2008)

Suppressor of cytokine signaling 3

SOCS3

PMF

Fernandez-Mercado et al. (2008); Fourouclas et al. (2008)

Polycythemia rubra vera protein 1

PRV1

ET, PV

Jelinek et al. (2007)

C-X-C chemokine receptor type 4

CXCR4

PMF

Bogani et al. (2008)

Retinoic acid receptor beta 2

RARβ2*

PMF

Jones et al. (2004); Jost et al. (2007)