Fig. 6

Assessment of cognitive functions between Dnmt1+/+ and Dnmt1+/− mice by Barnes maze at 12 months of age. The same groups of mice as in Fig. 3 were used for this test, and statistical analyses were performed as described in Fig 2. a Improvement of escape latency with the number of trial days. Dnmt1+/− mice had worse cognitive performance at the beginning of the test as well as at the end of the test (p = 0.038), although their learning ability and relative short-term memories were not severely impaired. b Graphs illustrating the typical path of a mouse to escape from the maze on days 1 and 5 of the experiment. The Dnmt1+/+ mice escaped more efficiently from the maze than Dnmt1+/− mice on both days