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Table 1 MiRNAs shown to be differentially expressed in drug-resistant breast cancers and the predicted mechanisms of drug resistance mediated through targeted genes

From: MicroRNA-mediated drug resistance in breast cancer

miRNA

Confirmed target

Mechanism of drug resistance

Chemotherapeutic drug

References

let-7

CASP3; ESR1; HMGA2; RAS

2; 3; 5

Cisplatin; cyclophophamide; doxorubicin; doxorubicin+verapamil; fulvestrant

Chen et al. (2010); Kovalchuk et al. (2008); Salter et al. (2008); Xin et al. (2009)

miR-7

EGFR; MRP1

1; 5

Cisplatin; VP-16

Liang et al. (2010); Pogribny et al. (2010)

miR-9

CDH1; SIRT1

3, 4

VP-16

Liang et al. 2010

miR-10

HOXD10

2, 3

Cisplatin, doxorubicin; doxorubicin+verapamil

Chen et al. (2010); Kovalchuk et al. (2008); Pogribny et al. (2010)

miR-15

BCL2; CCNE1; FGF7; WNT3A

3, 4

Doxorubicin; taxol

Kovalchuk et al. (2008); Zhou et al. (2010)

miR-16

BCL2; CCND1

2

Docetaxel; doxorubicin; doxorubicin+verapamil; taxol

Kastl et al. (2011); Kovalchuk et al. (2008); Zhou et al. 2010

mir-17

AIB1; BRCA1; E2F1; CCND1; RBl2

2; 5

Cyclophosphamide; doxorubicin; VP-16

Kovalchuk et al. (2008); Liang et al. (2010); Salter et al. (2008)

miR-19

ESR1; CCDN1; PTEN; SOCS1; TNF

2; 3; 5

Doxorubicin + verapamil

Chen et al. (2010)

miR-20

CDKN1A; E2F1; HIF-1α; RBL2; STAT3; VEGF

2; 3

Doxorubicin; taxol

Kovalchuk et al. (2008); Zhao et al. (2008)

miR-21

BCL2; CDC25; hMSH2; hMSH6; MASPIN; PDCD4; PTEN; RECK; RASGRP1; TIMP3; TPM1

2; 3

Doxorubicin; doxorubicin + verapamil; taxol

Chen et al. (2010); Kovalchuk et al. (2008); Mei et al. (2010)

miR-22

ESR1; PTEN

2; 5

Doxorubicin

Kovalchuk et al. (2008)

miR-23

PTEN

2

VP-16

Liang et al. (2010)

miR-27

CYPB1

1

Doxorubicin; taxol

Kovalchuk et al. (2008); Zhou et al. (2010)

miR-28

BRCA1

2

Doxorubicin

Kovalchuk et al. (2008)

miR-29

ADAM12; ADAMTS9; ADAMTS13; DNMT1; DNMT3A; DNMT3B; CDC42; CDK6; ITGA11

2, 3, 5

Cisplatin; doxorubicin; taxol; VP-16

Kovalchuk et al. (2008); Liang et al. (2010); Pogribny et al. (2010); Zhou et al. (2010)

miR-30

CTGF

3

Docetaxel; taxol

Kastl et al. (2011); Zhou et al. (2010)

miR-31

FZD3, ITGA5, M-RIP, MMP16, RDX, RHOA

3

Doxorubicin; doxorubicin + verapamil

Chen et al. (2010); Kovalchuk et al. (2008)

miR-32

PCAF

5

Doxorubicin + verapamil

Chen et al. (2010)

miR-34

BCL2; BIRC3; CCDN1; CCNE, CDK4; CDK6; E2F3, MET

2; 3

Docetaxel; doxorubicin; doxorubicin+verapamil

Chen et al. (2010); Kastl et al. (2011); Kovalchuk et al. (2008)

miR-93

E2F1; FUS1

2

Doxorubicin

Kovalchuk et al. (2008)

miR-100

ATM; PlK1

2; 3

Doxorubicin; doxorubicin + verapamil; taxol

Chen et al. (2010); Kovalchuk et al. (2008); Zhao et al. (2008)

miR-101

ATM; ESR1; EZH2

2; 4; 5

Tamoxifen

Sachdeva et al. (2011)

miR-106

AIB1; BRMS1; E2F1; P21; RB1

2; 3; 5

Doxorubicin; taxol

Kovalchuk et al. (2008); Zhao et al. (2008)

miR-107

CDK6

2

Doxorubicin

Kovalchuk et al. (2008)

miR-125

BAK1; CYP24; HER2/3; P53

1; 2

Docetaxel; doxorubicin; taxol

Kastl et al. (2011); Kovalchuk et al. (2008); Zhou et al. (2010)

miR-126

IRS1; P38

2; 3

Docetaxel; cisplatin

Kastl et al. (2011); Pogribny et al. (2010)

miR-127

BCL6

2

Cisplatin; doxorubicin

Pogribny et al. (2010); Kovalchuk et al. (2008); Saito et al. (2006)

miR-128

TGFBRI

3

Doxorubicin + verapamil; letrozole

Chen et al. (2010); Masri et al. (2010)

miR-132

MECP2; MMP9

3; 4

Cisplatin; doxorubicin

Kovalchuk et al. (2008); Pogribny et al. (2010)

miR-140

HDAC4

4

Doxorubicin; taxol

Kovalchuk et al. (2008); Zhao et al. (2008)

miR-141

APC; hMSH2; ZEB1

2; 3

Cisplatin; docetaxel; doxorubicin

Kastl et al. (2011); Kovalchuk et al. (2008); Pogribny et al. (2010)

miR-145

ESR1; IGFR; IRS1; MUC1; RTNK; SOX2

2; 3

Doxorubicin + verapamil

Chen et al. (2010)

miR146

BRCA1

2

Cisplatin; doxorubicin + verapamil; taxol

Chen et al. (2010); Pogribny et al. (2010); Zhou et al. (2010)

miR-148

DNMT1; DNMT3B; MSK1

3; 4

Doxrubicin + verapamil; doxorubicin

Chen et al. (2010); Kovalchuk et al. (2008)

miR-152

DNMT1

4

Doxorubicin

Kovalchuk et al. (2008)

miR-155

FOXO3; RHOA

2; 3

Doxorubicin

Kovalchuk et al. (2008)

miR-181

ATM; BCL2; HOXA11; PCAF; SIRT1; TIMP3

2; 3; 4

Doxorubicin; doxorubicin + verapamil; fulvestrant;

Chen et al. (2010); Kovalchuk et al. (2008); Xin et al. (2009)

miR-182

BRCA1

2

Doxorubicin

Kovalchuk et al. (2008)

miR-194

CDH2; DNMT3A; HBEGF; MDM2; MECP2; RAC1; SOCS2

2; 3; 4

Cisplatin; doxorubicin

Kovalchuk et al. (2008); Pogribny et al. (2010)

miR-196

ANXA1

3

Doxorubicin + verapamil

Chen et al. (2010)

miR-196

ANXA1; HOXB8

3

Cisplatin

Pogribny et al. (2010)

miR-199

DYRK1A; SIRT1

2; 4

Doxorubicin; fulvestrant

Xin et al. (2009); Kovalchuk et al. (2008)

miR-200

CTNNB1; MSN; WASF3; ZEB1; ZEB2

3

Actinomycin D; cisplatin; doxorubicin; doxorubicin + verapamil; epothilone B; paclitaxel; vincristine

Chen et al. (2010); Cochrane et al. (2009); Kovalchuk et al. (2008); Pogribny et al. (2010)

miR-204

SIRT1

4

Fulvestrant

Xin et al. (2009)

miR-205

E2F1; HER3; PTEN; VEGFA; ZEB1; ZEB2

2; 3; 5

Cisplatin; doxorubicin; gefitinib; lapatinib

Iorio et al. (2009); Kovalchuk et al. (2008); Pogribny et al. (2010)

miR-206

ESR1; GJA1; HGFR; IGF1; NOTCH3

2; 3; 5

Cisplatin, doxorubicin; doxorubicin + verapamil

Chen et al. (2010); Kovalchuk et al. (2008); Pogribny et al. (2010)

miR-211

TGFBR2

3

Fulvestrant

Xin et al. (2009)

miR-212

PED; MECP2; MMP9

2; 4; 5

Doxorubicin; fulvestrant

Kovalchuk et al. (2008); Xin et al. (2009)

miR-214

ING4; LF; PLXNB1; PTEN

2

Cisplatin; doxorubicin

Kovalchuk et al. (2008); Pogribny et al. (2010)

miR-216

PTEN

2

Fulvestrant

Xin et al. (2009)

miR-221/222

BMF; ESR1; FOXO3; P27; P57; PTEN

2; 3; 5

Cisplatin; doxorubicin; doxorubicin + verapamil; fulvestrant; tamoxifen

Chen et al. (2010); Kovalchuk et al. (2008); Miller et al. (2008); Pogribny et al. (2010); Rao et al. (2011); Xin et al. (2009); Zhao et al. (2008)

miR-224

CDC42

2

Doxorubicin

Kovalchuk et al. (2008)

miR-326

MRP1

1

Doxorubicin; VP-16

Kovalchuk et al. (2008); Liang et al. (2010)

miR-328

BCRP

1

Fulvestrant; mitoxantrone

Pan et al. (2009); Xin et al. (2009)

miR-331

E2F1; HER2

2; 5

Doxorubicin

Kovalchuk et al. (2008)

miR-342

JMJD (putative)

4

Cisplatin; doxorubicin

Kovalchuk et al. (2008); Pogribny et al. (2010)

miR-345

MRP1

1

Cisplatin; doxorubicin

Kovalchuk et al. (2008); Pogribny et al. (2010)

miR-346

NRIP1

2

Fulvestrant

Xin et al. (2009)

miR-373/520

RAD23B (putative)

2

Fulvestrant

Xin et al. (2009)

miR-375

MTPN; RASD5; JAK2; 14-3-3zeta; PDK1

2

Doxorubicin

Kovalchuk et al. (2008)

miR-429

ZEB1

3

Cisplatin; docetaxel; doxorubicin + verapamil; VP-16

Chen et al. (2010); Kastl et al. (2011); Liang et al. (2010); Pogribny et al. (2010)

miR-451

MDR1

1

Doxorubicin

Kovalchuk et al. (2008)

miR-489

MRP2 (putative)

1

Cisplatin; doxorubicin

Kovalchuk et al. (2008); Pogribny et al. (2010)

  1. Mechanism of drug resistance: 1 Defense, 2 Cellular response, 3 EMT, 4 Epigenetic, 5 Hormone receptor status