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Table 1 CpGs, histone modifications, and other factors or miRNAs that affect the expression of epigenetically regulated mucin genes

From: Epigenetic regulation of mucin genes in human cancers

Mucins

Promoter methylation sites

Histone modification

Factors or miRNA

MUC1

−70 to +20

H3-me2K9, aceK9

miR-125b, miRNA-145, miR-1226

MUC2

−3,269, −3,199, −2,331, −1,912, −338 to +158

H3-me2K4, me3K4, meK9, me2K9, aceK9, me2K27, aceK27, H3-ace, H4-ace

DNMT1, HDAC2

MUC3A

−345 to −75

N.D.

N.D.

MUC4

−121 to −81a

H3-ace, me2K9, aceK9, me3K27

Sp1, DNMT3A, DNMT3B, HDAC1, HDAC3

−170 to −102b

MUC5AC

−3,718 to −3,670

H3-me2K9, aceK9

N.D.

MUC5B

−2,677/−2,163

H3-me2K4, me3K4, meK9

DNMT1, HDAC2

−434/−421

me2K9, aceK9, me2K27, aceK27

MUC17

−179 to +52

H3-me2K9, aceK9

N.D.

  1. ND not determined
  2. aRegion reported by Vincent et al.
  3. bRegion reported by Yamada et al.