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Fig. 1 | Clinical Epigenetics

Fig. 1

From: ABT-737 and/or folate reverse the PDGF-induced alterations in the mitochondrial apoptotic pathway in low-grade glioma patients

Fig. 1

PDGF pathway activation correlates with the low degree of global DNA methylation and the presence of the apoptosis evasion phenotype in low-grade glioma (LGG). a Correlation between the degree of global DNA methylation (i.e., the number of 5-methylcytosine, 5mC) and the degree of apoptosis (i.e., the DEVDase activity), the degree of PDGFrβ activity and the degree of apoptosis (i.e., the DEVDase activity), and between the degree of PDGFrβ activity and the degree of global DNA methylation (i.e., the number of 5-methylcytosine, 5mC) in 65 LGG. 5mC was estimated by using the Methylamp Global DNA Methylation Quantification kit (Epigentek-Euromedex, France). PDGFrβ activity was assessed by using the HTScan® PDGF Receptor β Kinase Assay Kit (Ozyme, France). DEVDase activity was measured as previously described (Cartron et al. 2002). b Representation of the patient number whose LGG is characterized by the presence of a high PDGFrβ activity (higher or equal to the median value), a low level of DNA methylation (lower to the median value), and a low DEVDase activity (lower to the median value). AII grade II astrocytoma, OAII grade II oligoastrocytoma, OII grade II oligodendrocytoma. c Kalpan–Meier estimates of survival time for patients whose tumors had a high PDGFrβ activity (higher or equal to the median value), a low level of DNA methylation (lower to the median value), and a low DEVDase activity (lower to the median value) (in black) and those whose tumors did not (in gray)

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