From: Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications
Cancer | IRS | Cellular phenotype | Molecular association | Reference | ||
---|---|---|---|---|---|---|
Higher clinical stage | Poorer histological grade | Survival | ||||
Cervical cancer | L1 | NR | PE | NR | NR | Shuangshoti et al. (2007) |
Cholangiocarcinoma | L1 | NR | PE | NR | PE for CIMP and TSG mutation | Kim et al. (2009a) |
Colorectal cancer | L1 | NR | PE | NR | NR | Chalitchagorn et al. (2004) |
L1 | NR | NR | NR | PE for MSS | Matsuzaki et al. (2005) | |
L1 | NR | NR | NR | PE for MSI and CIN | Deng et al. (2006) | |
L1 | NR | NR | NR | NE for MSI | Estecio et al. (2007) | |
L1 | PE | PE in mucinous histology | NR | NE for MSI and TSG mutation | Iacopetta et al. (2007) | |
L1 | NR | NR | NR | NE for MSI and CIMP | Ogino et al. (2008a) | |
PE for chromosomal alteration in non-MSI tumor | ||||||
L1 | NR | NR | PE | NR | Ogino et al. (2008b) | |
L1 | NR | NR | NR | NE for SNPSs in one-carbon pathway genes. | Hazra et al. (2010) | |
L1 | NR | NR | NR | LINE-1 methylation level correlated between synchronous cancer pairs from the same individuals. | Nosho et al. (2009a) | |
L1 | NR | NR | NR | NE for DNMT3B- positive tumors | Nosho et al. (2009b) | |
L1 | NR | NR | NR | PE for CIMP | An et al. (2010) | |
L1 | NR | NR | PE in proximal colon cancer NE in distal colon cancer | NR | ||
L1 | NR | NR | PE | PE for MSI, CIMP, CIN, TSG mutation and TSG expression | Baba et al. (2010) | |
L1 | NR | NR | NR | NE for MSI and methylation index | Goel et al. (2010) | |
PE for MSS HNPCC | ||||||
L1 | NR | PE | NR | NR | Ibrahim et al. (2011) | |
L1 | NR | NR | PE | NE for MSI and CIMP | Kawakami et al. (2011) | |
Alu, L1 | NE | PE | NR | NR | Kwon et al. (2010) | |
Ependymoma | Alu | NR | PE | NR | NR | Xie et al. (2010) |
Gastric cancer | Alu | NR | PE | NR | NR | Park et al. (2009) |
L1 | NR | PE | NR | NR | Park et al. (2009) | |
L1 | NR | NR | NR | PE for folate metabolizing gene polymorphisms | Hou et al. (2010) | |
Gastrointestinal stromal cancer | L1 | PE | NR | NR | NR | Igarashi et al. (2010) |
Head and neck cancer | L1 | PE | NR | NR | NR | Smith et al. (2007) |
L1 | NR | NR | PE especially HPV 16 negative SCC | NR | Furniss et al. (2008) | |
L1 | NS | NS | NR | NR | Subbalekha et al. (2009) | |
Hepatocellular carcinoma | L1 | PE | PE | NR | NR | Tangkijvanich et al. (2007) |
Alu | NE | PE | NR | NR | Lee et al. (2009) | |
L1 | PE | PE | NR | NR | Lee et al. (2009) | |
L1 | NR | PE | NR | NR | Kim et al. (2009b) | |
L1 | NR | NR | PE | NR | Formeister et al. (2010) | |
Multiple myeloma (MM) | Alu | NR | PE | NR | NE for hyperdiploid MM | Bollati et al. (2009) |
L1 | NR | PE | NR | PE for chromosomal translocation | Bollati et al. (2009) | |
Nerve tumor | L1 | NR | NE | NR | NR | Feber et al. (2011) |
Neuroendocrine tumor | Alu | NR | NE | PE | PE for TSG methylation | Choi et al. (2007) |
L1 | NR | NE | PE | PE for chromosomal alteration and gene methylation | Choi et al. (2007) | |
Non-small cell lung cancer (NSCLC) | L1 | NR | SCC > adenocarcinoma (P < 0.001) | NR | NR | Jin et al. (2009) |
L1 | NR | NR | PE | NR | Saito et al. (2010) | |
Odontogenic tumor | L1 | NR | Ameloblastoma > KCOT (P = 0.001) | NR | NR | Kitkumthorn and Mutirangura (2010) |
Ovarian cancer | L1 | NS | NE | PE | NR | (Pattamadilok et al. 2008) |
L1 | NR | NR | NR | PE with TSG expression | Woloszynska-Read et al. (2008) | |
L1 | NR | NR | NR | PE for follow-up patients treated with decitabine (P < 0.001) | Fang et al. (2010) | |
L1 | PE | NR | NR | PE for TSG methylation | Woloszynska-Read et al. (2011) | |
Ovarian clear cell carcinoma | L1 | PE | NR | NR | NR | Iramaneerat et al. (2011) |
HERV-E | PE | NR | NR | NR | Iramaneerat et al. (2011) | |
HERV-K | PE | NR | PE | NR | Iramaneerat et al. (2011) | |
Pancreatic cancer | L1 | NR | NR | NR | PE for MTHFR polymorphisms | Matsubayashi et al. (2005) |
Prostate cancer | L1 | PE | NR | NR | NR | Santourlidis et al. (1999) |
L1 | PE | NR | PE | PE with chromosomal aberration | Schulz et al. (2002) | |
L1 | PE | NR | NR | NR | Kindich et al. (2006) | |
Alu | PE | PE | NR | NR | Cho et al. (2007) | |
L1 | PE | PE | NR | NR | Cho et al. (2007) | |
L1 | NR | NR | PE | NR | Yegnasubramanian et al. (2008) | |
L1 | NR | PE | NR | NR | Cho et al. (2009) | |
Urothelial cancer | L1 | PE | PE | NR | NR | Florl et al. (1999) |
L1 | PE | PE | NE | NR | Neuhausen et al. (2006) | |
L1 | NR | NR | NR | PE for Met oncogene alternate transcript | Wolff et al. (2010) |