Fig. 3
From: Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications
Intragenic hypomethylated LINE-1s repress host gene expression via AGO2. The schematic demonstrates that the same gene from three different cells has different levels of intragenic LINE-1 methylation. a Hypermethylated LINE-1. b Partially methylated LINE-1. c Hypomethylated LINE-1. LINE-1 RNA is produced when the methylation of the LINE-1 5′ UTR is reduced. The LINE-1 RNA–pre-mRNA complex is bound by AGO2, and mRNA production is prevented