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Table 2 Genes identified by microarray, ChIP-Seq, and genomic PCR as up-regulated subsequent to GRPR signaling via HP1β

From: Identification of ChIP-seq mapped targets of HP1β due to bombesin/GRP receptor activation

Gene ID

ChIP-Seq detected

gPCR confirmed

RT-PCR (fold change)

Pubmed ID

Chromo

Gene description

Antag vs. control (fold change)

HP1β siRNA vs control (fold change)

FAM13A

Yes

Yes

2.4 ± 0.6

10,144

4

Family with sequence similarity 13, member A

2.4

5.5

GBE1

Yes

Yes

3.3 ± 0.7

2,632

3

Glucan (1,4-alpha-), branching enzyme 1

2.8

4.2

PLK3

Yes

Yes

2.8 ± 0.7

1,263

1

Polo-like kinase 3

2.0

2.6

SLCO1B3

Yes

Yes

4.2 ± 2.12

28,234

12

Solute carrier organic anion transporter family, member 1B3

2.0

3.5

PLOD2

Yes

No

n.r.

5,352

3

Procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

2.2

5.2

ACSF2

No

No

n.r.

80,221

17

Acyl-CoA synthetase family member 2

2.1

2.3

AKAP7

No

No

n.r.

9,465

6

A kinase (PRKA) anchor protein 7

5.0

14.1

APOL1

No

No

n.r.

8,542

22

apolipoprotein L, 1

2.0

3.0

ARL14

No

No

n.r.

80,117

3

ADP-ribosylation factor-like 14

2.4

4.6

BCL3

No

No

n.r.

602

19

B-cell CLL/lymphom a 3

3.4

3.5

BDH2

No

No

n.r.

56,898

4

3-hydroxybutyrate dehydrogenase, type 2

2.0

3.1

BNIP3L

No

No

n.r.

665

8

BCL2/adenovirus E1B 19 kDa interacting protein 3-like

2.4

6.0

CCDC64

No

No

n.r.

92,558

12

Coiled-coil domain containing 64

2.1

3.0

CDKN1A

No

No

n.r.

12,575

17

Cyclin dependent kinase inhibitor 1A (P21)

2.5

4.8

CDKN1C

No

No

n.r.

1,028

11

Cyclin dependent kinase inhibitor 1 C (p57, Kip2)

3.3

7.6

CLIC3

No

No

n.r.

9022

9

Chloride intracellular channel 3

2.7

3.0

CYP3A5P2

No

No

n.r.

79,424

7

Cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 2

2.2

2.4

DUSP6

No

No

n.r.

1,848

12

Dual specificity phosphatase 6

2.1

2.5

ENO2

No

No

n.r.

2,026

12

Enolase 2 (gamma, neuronal)

3.0

4.9

FABP1

No

No

n.r.

2,168

2

Fatty acid binding protein 1, liver

3.2

2.8

FOSL1

No

No

n.r.

8,061

11

FOS-like antigen 1

3.0

2.2

FSCN1

No

No

n.r.

6,624

7

Fascin homolog 1, actin-bundling protein (Strongylocent rotus purpuratus)

3.1

3.8

FXYD3

No

No

n.r.

5,349

19

FXYD domain containing ion transport regulator 3

2.4

4.1

GAL3ST1

No

No

n.r.

9,514

22

Galactose-3-Osulfotransferase 1

2.0

2.9

GEM

No

No

n.r.

2,669

8

GTP binding protein overexpressed in skeletal muscle

3.8

5.2

GPR87

No

No

n.r.

53,836

3

G protein coupled receptor 87

5.3

2.5

HMGCS2

No

No

n.r.

3,158

1

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

2.6

2.6

HRH1

No

No

n.r.

3,269

3

Histamine receptor H1

2.3

2.9

KDM4B

No

No

n.r.

23,030

19

Lysine (K)-specific demethylase 4B

2.4

2.9

LAMA3

No

No

n.r.

3,909

18

Laminin, alpha 3

2.4

2.1

LDLR

No

No

n.r.

3,949

19

Low density lipoprotein receptor

2.1

2.7

LGALS1

No

No

n.r.

3,956

22

Lectin, galactosidebinding, soluble, 1

2.2

2.5

MAFF

No

No

n.r.

23,764

22

v-maf musculoaponeurotic fibrosarcoma oncogene homolog F

2.0

3.8

NAB2

No

No

n.r.

4,665

12

NGFI-A binding protein 2 (EGR1 binding protein 2)

2.1

3.2

NDRG1

No

No

n.r.

10,397

8

N-myc downstream regulated 1

5.7

18.5

NDUFA4L2

No

No

n.r.

56,901

12

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2

9.8

9.2

P4HA1

No

No

n.r.

5,033

10

Prolyl 4-hydroxylase, alpha polypeptide I

3.2

7.9

PDE9A

No

No

n.r.

5,152

21

Phosphodiesterase 9A

2.0

2.5

PER2

No

No

n.r.

8,864

2

Period homolog 2 (Drosophila)

2.5

3.5

PHLDA1

No

No

n.r.

22,822

12

Pleckstrin homology-like domain, family A, member 1

2.2

3.9

PTK6

No

No

n.r.

5,753

20

PTK6 protein tyrosine kinase 6

2.2

2.4

PTPRH

No

No

n.r.

5,794

19

Protein tyrosine phosphatase, receptor type, H

2.1

2.3

PTPRR

No

No

n.r.

5,801

12

Protein tyrosine phosphatase, receptor type, R

6.5

12.0

RARRES1

No

No

n.r.

5918

3

Retinoic acid receptor responder (tazarotene induced) 1

2.4

3.8

RHOF

No

No

n.r.

54,509

12

Ras homolog gene family, member F (in filopodia)

2.1

3.1

SCARF1

No

No

n.r.

8,578

17

Scavenger receptor class F, member 1

2.5

4.2

SGK1

No

No

n.r.

6,446

6

Serum/glucoco rticoid regulated kinase 1

2.1

3.2

SERPINB9

No

No

n.r.

5,272

6

Serpin peptidase inhibitor, clade B (ovalbumin), member 9

2.5

3.8

SLC11A2

No

No

n.r.

4,891

12

Solute carrier family 11 8(proton-coupled divalent metal ion)

3.0

3.7

SPAG4

No

No

n.r.

6,676

20

Sperm associated antigen 4

3.5

4.8

TFF2

No

No

n.r.

7,032

21

Trefoil factor 2

2.3

2.5

ZNF274

No

No

n.r.

10,782

19

Zinc finger protein 274

3.1

3.2