Epigenetic regulation of S100 protein expression

Leśniak, Wiesława

doi:10.1007/s13148-011-0023-9

Clinical Epigenetics

Table 1 Changes in S100 gene methylation and expression in cancer

From: Epigenetic regulation of S100 protein expression

S100 protein	Cell/tissue	S100 protein expression	Gene region examined	Methylation (cancer vs. control)	Reference
S100A2	Breast cancer cell lines and biopsies	↓	Proximal promoter Upstream promoter 1st intron	↑	Wicki et al. 1997;
				No change
				No change
	Prostate cancer cell lines and tissues	↓	Proximal promoter	No change	Rehman et al. 2005;
	Non-small lung cancer cell lines	↓	1st intron	↑	Feng et al. 2001;
	Head and neck cancer lymph metastases	↓	1st intron	↑	Zhang et al. 2007;
S100A4	Rat mammary cancer cell lines	↑	1st intron, TATA box region	↓	Chen et al. 1999;
	Rat mammary cancer cell lines	↑	Upstream promoter	No change	Chen et al. 1999;
	Colon adenocarcinoma cell lines	↑	1st intron	↓	Nakamura et al. 1998;
			Upstream promoter	No change
			Downstream region	No change
	Pancreatic cancer cell lines	↑	1st intron	↓	Rosty et al. 2002;
	Endometrium grade III tumors and cell lines	↑	1st intron	↓	Xie et al. 2007;
	Medulloblastoma tissue and cell lines	↑	1st intron	↓	Lindsey et al. 2007;
	Epidermal cancer cell lines and squamous cell carcinoma	↓	1st intron	↑	Li et al. 2009
S100A6	Prostate cancer tissue and cell lines	↓	Promoter/1st exon	↑	Rehman et al. 2005;
	Medulloblastoma cell lines	↓	Promoter/1st exon	↑	Lindsey et al. 2007;
	Medulloblastomas	↓	Promoter/1st exon	No change	Anderton et al. 2008
	Gastric cancer tissue	↑	1st intron/2nd exon	↓	Wang et al. 2010;
S100A10	Primary human pituitary tumors	↓	Proximal promoter	↑	Dudley et al. 2008;
S100A10	Medulloblastoma tissue and cell lines	↓	Proximal promoter	↑	Lindsey et al. 2007; Anderton et al. 2008
S100P	Primary pancreatic adenocarcinomas	↑	Promoter/1st exon	↓	Sato et al. 2004;
S100P	Prostate cancer cell lines	↑	Promoter/1st exon	↓	Wang et al. 2007

↑ increase, ↓ decrease

Back to article page

ISSN: 1868-7083

Contact us

Submission enquiries: avalyn.villar@springernature.com
General enquiries: info@biomedcentral.com