Table 3 Pharmaceutical epigenetic effects
Chemical | Reported epigenetic effect |
|---|---|
Valproic acid | Histone deacetylase inhibition (Phiel et al. 2001) |
5-Fluro-2′-deoxyuridine | DNA hypermethylation (Nyce et al. 1993) |
Hydralazine | Inhibition of DNA methylation (Gorelik and Richardson 2009) |
Procainamide | Inhibition of DNA methylation (Gorelik and Richardson 2009) |
Retinoic acid | Reduction of DNA methylation (Kuriyama et al. 2008) |
Methotrexate | Reduction of DNA methylation (Toffoli et al. 2003; Friso et al. 2002) |
Suberoylanilide hydroxamic acid | Histone deacetylase inhibition (Duvic and Vu 2007) |
Sodium butyrate | Histone deacetylase inhibition (Reuse et al. 2009) |