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Table 2 HDACs in humans and in Saccharomyces cerevisiae

From: The transposon-driven evolutionary origin and basis of histone deacetylase functions and limitations in disease prevention

Mechanism Requirement

Class

S. cerevisiae

Humans

Zinc ion (Zn2+)

1

Rpd3

HDAC1

Hos2

HDAC2

Hos1

HDAC3

HDAC8

2

Hda1

HDAC4

Hos3

HDAC5

HDAC6

HDAC7

HDAC9

HDAC10

4

 

HDAC11

Nicotinamide adenine dinucleotide (NAD+)

3 (Sirtuins)

Sir2

SIRT1–SIRT7

Hst1

Hst2

Hst3

Hst4