From: 5-Aza-2′-deoxycytidine stress response and apoptosis in prostate cancer
Enzymes | Control | 5-AzadC (nM) | |||||||
---|---|---|---|---|---|---|---|---|---|
10 | 20 | 35 | 50 | 75 | 100 | 250 | 500 | ||
DNMT | 100 | 71.23 | 50.36 | 5.14 | 2.32 | – | – | – | – |
HDAC | 100 | 90.62 | 81.07 | nd | 73.34 | 61.58 | nd | nd | nd |
Caspase-3 | – | – | – | – | – | 2.3 ± 1.73 | 5.67 ± 3.46 | 27.5 ± 8.40 | 41.49 ± 7.0 |