Fig. 2
From: The elements of human cyclin D1 promoter and regulation involved
The main three signal transduction pathways on human cyclin D1 promoter. Three pathways are MAPK, PI3k/Akt, and Wnt. MAPK pathways regulate cyclin D1 promoter via AP-1 and Ets elements. Elements such as LEF/TCF and CRE are responsible for PI3k/Akt and Wnt pathways and GSK3β is their cross-talk point. PETN can cross-talk between MAPK and PI3k/Akt pathway