Fig. 1
From: Epigenetic targets of bioactive dietary components for cancer prevention and therapy
Schematic diagram illustrating DNA methylation catalyzed by DNMTs. a The DNA methylation process is catalyzed by the DNMTs by adding a methyl group (CH3) from SAM to the 5-position of the cytosine ring. SAM donates a methyl group and is then converted into SAH. b Methylated cytosine moieties in CpG dinucleotides within a gene promoter. c DNMTs convert unmethylated DNA into methylated DNA in chromatin. White circles unmethylated CpG sites, green circles hypermethylated CpG sites, yellow circles histone proteins, red thread DNA