Skip to main content

Table 1 Evidence for sirtuin proteins being involved in life span and age-related disease

From: The sirtuins in the pathogenesis of cancer

Sirtuin Size Localization Enzymatic activity Interactions Function Mouse knockout models
SIRT1 82 kDa Nucleus Deacetylase ACS1, AR, AROS, BCL11A, COUP-TF, CTIP2, DBC1, FOXO1, FOXO4, E2F1, eNOS, histones H1, H4, IRS2, KU70, LXR, MEF2, NBS1, NCOR, NF-κB-p65, p300, p53, p73, PGC1a, RB, SMAD7, SUV39H1, TAT, TLE1, TORC2, WRN Glucose production, insulin secretion, fatty-acid mobilization/oxidation (liver/skeletal muscle), cholesterol regulation, adipokine regulation, neuroprotection, stress resistance, apoptosis control, cell differentiation, mediation of calorie restriction Sirt1−/−: most mice die perinatally, retinal, bone, and cardiac defects
SIRT2 42 kDa Cytosol Deacetylase FOXO3a, histones H3, H4, HOXA10, 14-3-3 protein, p53, tubulin, Tubulin deacetylation, cell cycle control Sirt2−/−: developmentally normal
SIRT3 44 kDa Mitochondria Deacetylase AceCS2, GDH complex I Thermogenesis/metabolism, ATP production, mitochondrial fatty-acid oxidation Sirt3−/−: developmentally normal, change in AcdCS2 activity, ATP levels and mitochondrial protein acetylation
SIRT4 35 kDa Mitochondria ADP ribosyltransferase GDH, IDE, ANT2/3 Insulin secretion Sirt4−/−: appear healthy, increased mitochondrial GDH activity
SIRT5 34 kDa Mitochondria Deacetylase CPS1 Urea cycle regulation Sirt5−/−: defect in the urea cycle
SIRT6 39 kDa Nucleus ADP ribosyltransferase Histone H3, NF-κB DNA repair, telomeric chromatin structure, NF-κB regulation, metabolism Sirt6−/−: progeroid syndrome, profound hypoglycemia, death at 4 weeks
SIRT7 48 kDa Nucleolus Deacetylase RNA polymerase I, p53 rDNA transcription Sirt7−/−: reduced life span, cardiomyopathy