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Table 1 Classification of human histone deacetylases

From: Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells

Class Human HDAC Yeast HDAC Co-factor Compartment Tissue distribution
I HDACs 1, 2, 3 and 8 RPD3 Zn Mostly nuclear Ubiquitous
IIa HDACs 4, 5, 7 and 9 HDA1 Zn Nuclear and cytoplasmic Heart: HDAC4, 5, 7 smooth muscle: HDAC4, 5, 7, 9 brain: HDAC4, 5, 9 placenta, pancreas: HDAC 7
IIb HDACs 6 and 10 HDA1 Zn Cytoplasmic Kidney, liver: HDAC 6, 10 pancreas, heart: HDAC 6 spleen: HDAC10
III SIRT 1–7 SIR2 NAD+ Nuclear (1,6,7), mitochondrial (3,4,5), cytoplasmic (2) See (Dali-Youcef et al. 2007) for a comprehensive overview
IV HDAC 11   Zn Nuclear and cytoplasmic Heart, smooth muscle, kidney, brain