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Table 2 Role of HDACs in viral infections

From: Histone deacetylases in viral infections

Virus HDAC Molecular mechanism Clinical effect References
DNA viruses
HBV HDAC1, 2 HBx forms a multiprotein complex HDAC1/2, MTA1, HIF-1 Angiogenesis and metastasis of HBV-associated HCC Semenza 2004; Yoo et al. 2008
HCMV HDAC3 HDAC3 represses the HCMV MIEP Repression of viral replication Meier 2001; Murphy et al. 2002
HSV-1 HDAC1 HDAC represses viral transcription during latency via HCF-1. ICP0 inhibits the HDAC1/CoREST complex and favor the HSV reactivation Control of HSV-1 latency and reactivation in neurons Wysocka et al. 2003, Everett et al. 2009
EBV HDAC1, 2, 7 Histone deacetylation in response to phosphorylated MEF-2D transcription factor. HDAC7 represses the Zp promoter. HDAC1/2 represses the TRF2 promoter binding Control of EBV latency Gruffat et al. 2002; Bryant and Farrell 2002; Zhou et al. 2009
HPV HDAC1 E7 viral oncoprotein disrupts the Rb/E2F/HDAC1 repressor complexes and favors cdc25A transcription. E7 binds HDAC and favor E2F2 transcription in keratinocytes. E7 recruits HDAC and blocks the IRF-1 transactivation function, a tumor suppressor E7 HPV favors carcinogenesis through binding to cellular factors involved in cell cycle regulation and differentiation Nguyen et al. 2002; Longworth & Laimins 2004; Park et al. 2000
RNA viruses
HCV HDAC HDAC favors the expression of HIF, a hepcidin regulator HCV-induced oxidative stress suppresses hepcidin expression Miura et al. 2008
HIV HDAC class I & class II & class III HDAC represses the HIV-1 LTR transcription through the formation of inhibitory complexes including HDACs and several transcription factors and repressor proteins. HIV-1 virion-associated HDAC1 could favor early post-entry events. SIRT1 regulates HIV transcription via Tat deacetylation Formation of HIV cellular reservoirs in both myeloid and lymphoid cells resulting in viral persistence Van Lint et al. 1996, Coull et al. 2000, Williams et al. 2006, Marban et al. 2005, Marban et al. 2007, Rohr et al. 2003; Reuse et al. 2009; Imai & Okamoto 2006; Jiang et al. 2007; Sorin et al. 2009; Pagans et al. 2005; Kwon et al. 2008; Zhang et al. 2009
RSV HDAC1 HDAC1 associates with STAT1 and Bcl-3 on the IL-8 promoter Decreased IL-8 production during airway inflammation to favor RSV replication Jamaluddin et al. 2005