|
Class I
|
HDAC1
|
Nucleus
|
AR, p53, E2F-1, SHP, STAT3, MyoD
|
|
HDAC2
|
Nucleus
|
STAT3, Bcl6, glucocorticoid receptor GATA-1, STAT-3,SHP, RelA, YY-1
|
|
HDAC3
|
Nucleus/cytoplasm
|
|
HDAC8
|
Nucleus
|
–
|
|
Class II
|
HDAC4
|
Nucleus/cytoplasm
|
GCMa, GATA-1, HP-1
|
|
HDAC5
|
Nucleus/cytoplasm
|
GCMa, Smad7, HP-1
|
|
HDAC6
|
Mostly cytoplasm
|
HSP70, Smad7, SHP, α-tubulin
|
|
HDAC7
|
Nucleus/cytoplasm
|
PLAG1, PLAG2
|
|
HDAC9
|
Nucleus/cytoplasm
|
–
|
|
HDAC10
|
Mostly cytoplasm
|
–
|
|
Class III
|
SIRT1
|
Nucleus
|
NF-κB, p53, FOXO
|
|
SIRT2
|
Cytoplasm
|
α-tubulin, H4
|
|
SIRT3
|
Nucleus/mitochondria
|
Acetyl–CoA synthetases
|
|
SIRT4
|
Mitochondria
|
Glutamate dehydrogenate
|
|
SIRT5
|
Mitochondria
|
–
|
|
SIRT6
|
Nucleus
|
DNA polymerase B
|
|
SIRT7
|
Nucleus
|
RNA polymerase 1
|
|
Class IV
|
HDAC11
|
Nucleus/cytoplasm
|
–
|
