Table 1 HDAC classification depending on sequence identity and domain organization
Histone classes | Members | Localization | Target proteins (partial list) |
|---|---|---|---|
Class I | HDAC1 | Nucleus | AR, p53, E2F-1, SHP, STAT3, MyoD |
HDAC2 | Nucleus | STAT3, Bcl6, glucocorticoid receptor GATA-1, STAT-3,SHP, RelA, YY-1 | |
HDAC3 | Nucleus/cytoplasm | ||
HDAC8 | Nucleus | – | |
Class II | HDAC4 | Nucleus/cytoplasm | GCMa, GATA-1, HP-1 |
HDAC5 | Nucleus/cytoplasm | GCMa, Smad7, HP-1 | |
HDAC6 | Mostly cytoplasm | HSP70, Smad7, SHP, α-tubulin | |
HDAC7 | Nucleus/cytoplasm | PLAG1, PLAG2 | |
HDAC9 | Nucleus/cytoplasm | – | |
HDAC10 | Mostly cytoplasm | – | |
Class III | SIRT1 | Nucleus | NF-κB, p53, FOXO |
SIRT2 | Cytoplasm | α-tubulin, H4 | |
SIRT3 | Nucleus/mitochondria | Acetyl–CoA synthetases | |
SIRT4 | Mitochondria | Glutamate dehydrogenate | |
SIRT5 | Mitochondria | – | |
SIRT6 | Nucleus | DNA polymerase B | |
SIRT7 | Nucleus | RNA polymerase 1 | |
Class IV | HDAC11 | Nucleus/cytoplasm | – |