Skip to main content

Table 1 HDAC classification depending on sequence identity and domain organization

From: Histone deacetylases in viral infections

Histone classes

Members

Localization

Target proteins (partial list)

Class I

HDAC1

Nucleus

AR, p53, E2F-1, SHP, STAT3, MyoD

HDAC2

Nucleus

STAT3, Bcl6, glucocorticoid receptor GATA-1, STAT-3,SHP, RelA, YY-1

HDAC3

Nucleus/cytoplasm

HDAC8

Nucleus

–

Class II

HDAC4

Nucleus/cytoplasm

GCMa, GATA-1, HP-1

HDAC5

Nucleus/cytoplasm

GCMa, Smad7, HP-1

HDAC6

Mostly cytoplasm

HSP70, Smad7, SHP, α-tubulin

HDAC7

Nucleus/cytoplasm

PLAG1, PLAG2

HDAC9

Nucleus/cytoplasm

–

HDAC10

Mostly cytoplasm

–

Class III

SIRT1

Nucleus

NF-κB, p53, FOXO

SIRT2

Cytoplasm

α-tubulin, H4

SIRT3

Nucleus/mitochondria

Acetyl–CoA synthetases

SIRT4

Mitochondria

Glutamate dehydrogenate

SIRT5

Mitochondria

–

SIRT6

Nucleus

DNA polymerase B

SIRT7

Nucleus

RNA polymerase 1

Class IV

HDAC11

Nucleus/cytoplasm

–