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Table 1 Tumor suppressor and oncogenic miRNAs and their target genes: The biological role of individual miRNA is correlated to the function of its target gene. IRS insulin receptor substrate-1 (oncogene), AT1R angiotensin II type 1 receptor, which is responsible for the activity of the main effector hormone, LATS2 serine/threonine-protein kinase (which is involved in P53 function), HES1 hairy and enhancer of split (tumor suppressor), E2F1 transcription factor (plays a crucial role in the control of cell cycle and action of tumor suppressor proteins)

From: Challenge and promise: the role of miRNA for pathogenesis and progression of malignant melanoma

Tumour suppressor miRNA

Target gene

Reference

Oncogenic miRNA

Target gene

Reference

Let-7

oncogeneRAS

Lujambio et al. 2008

miR-372

P53

Ma et al. 2007

miR-17-5p

c-Myc

Ma et al. 2007

miR-373

LATS2

Lujambio et al. 2008

miR-20a

c-Myc

Ma et al. 2007

miR-155

AT1R

Lujambio et al. 2008

miR-126

IRS-1

Saito et al. 2009

miR-9-1

HES1

Ma et al. 2007

miR-15a

BCL-2

Lujambio et al. 2008

miR-17-92

E2F1

Liu et al. 2008

miR-16

BCL-2

Lujambio et al. 2008

miR-221

P27

Rigel and Carucci 2000