Fig. 1
From: Challenge and promise: the role of miRNA for pathogenesis and progression of malignant melanoma
miRNA biogenesis: miRNAs originate in the nucleus as hairpin precursors and then are processed by the RNaseIII enzymes, Drosha and Dicer, to yield double-stranded RNA. One strand is selected to function as mature miRNA and loaded into the RISC, while another strand is degraded. Then miRNA binds imperfectly with its target mRNA in animal, whereas it binds with perfect complementarity in plants, resulting in mRNA translational repression