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  1. Short report

    The epigenomic basis of common diseases

    A report of the 6th Epigenomics of Common Diseases Conference held at the Wellcome Genome Campus in Hinxton, Cambridge, UK, on 1–4 November 2016.

    Euan J. Rodger and Aniruddha Chatterjee

    Clinical Epigenetics 2017 9:5

    Published on: 19 January 2017

  2. Research

    The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry

    RRx-001, a dinitroazetidine derivative, is a novel anticancer agent currently in phase II clinical trials. It mediates immunomodulatory effects either directly through polarization of tumor associated macropha...

    Hongjuan Zhao, Shoucheng Ning, Rosalie Nolley, Jan Scicinski, Bryan Oronsky, Susan J. Knox and Donna M. Peehl

    Clinical Epigenetics 2017 9:4

    Published on: 19 January 2017

  3. Letter to the Editor

    Combining omics data to identify genes associated with allergic rhinitis

    Allergic rhinitis is a common chronic disorder characterized by immunoglobulin E-mediated inflammation. To identify new genes associated with this trait, we performed genome- and epigenome-wide association stu...

    Andréanne Morin, Michel Laviolette, Tomi Pastinen, Louis-Philippe Boulet and Catherine Laprise

    Clinical Epigenetics 2017 9:3

    Published on: 18 January 2017

  4. Research

    Improved results of LINE-1 methylation analysis in formalin-fixed, paraffin-embedded tissues with the application of a heating step during the DNA extraction process

    Formalin-fixed, paraffin-embedded (FFPE) tissues are important resources for profiling DNA methylation changes and for studying a variety of diseases. However, formalin fixation introduces inter-strand crossli...

    Xianyu Wen, Seorin Jeong, Younghoon Kim, Jeong Mo Bae, Nam Yun Cho, Jung Ho Kim and Gyeong Hoon Kang

    Clinical Epigenetics 2017 9:1

    Published on: 13 January 2017

  5. Research

    Promoter hypermethylation of SHOX2 and SEPT9 is a potential biomarker for minimally invasive diagnosis in adenocarcinomas of the biliary tract

    Biliary tract carcinoma (BTC) is a fatal malignancy which aggressiveness contrasts sharply with its relatively mild and late clinical presentation. Novel molecular markers for early diagnosis and precise treat...

    V. Branchi, P. Schaefer, A. Semaan, A. Kania, P. Lingohr, J. C. Kalff, N. Schäfer, G. Kristiansen, D. Dietrich and H. Matthaei

    Clinical Epigenetics 2016 8:133

    Published on: 12 December 2016

  6. Research

    Characterization of TET and IDH gene expression in chronic lymphocytic leukemia: comparison with normal B cells and prognostic significance

    Chronic lymphocytic leukemia (CLL) is the most common hematological malignancy in western countries, characterized by a heterogeneous clinical course. Although genetic studies have identified chromosomal aberr...

    Michaël Van Damme, Emerence Crompot, Nathalie Meuleman, Marie Maerevoet, Philippe Mineur, Dominique Bron, Laurence Lagneaux and Basile Stamatopoulos

    Clinical Epigenetics 2016 8:132

    Published on: 7 December 2016

  7. Research

    Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis

    Psoriasis is a chronic inflammatory skin disease characterized by epidermal hyperproliferation and altered keratinocyte differentiation and inflammation and is caused by the interplay of genetic and environmen...

    Fusheng Zhou, Changbing Shen, Jingkai Xu, Jing Gao, Xiaodong Zheng, Randy Ko, Jinfa Dou, Yuyan Cheng, Caihong Zhu, Shuangjun Xu, Xianfa Tang, Xianbo Zuo, Xianyong Yin, Yong Cui, Liangdan Sun, Lam C. Tsoi…

    Clinical Epigenetics 2016 8:131

    Published on: 5 December 2016

  8. Short report

    A methylation PCR method determines FMR1 activation ratios and differentiates premutation allele mosaicism in carrier siblings

    Epigenetic modifications of the fragile X mental retardation 1 (FMR1) gene locus may impact the risk for reproductive and neurological disorders associated with expanded trinucleotide repeats and methylation stat...

    Andrew G. Hadd, Stela Filipovic-Sadic, Lili Zhou, Arianna Williams, Gary J. Latham, Elizabeth Berry-Kravis and Deborah A. Hall

    Clinical Epigenetics 2016 8:130

    Published on: 1 December 2016

  9. Research

    Aberrant DNA hypermethylation-silenced SOX21-AS1 gene expression and its clinical importance in oral cancer

    Long noncoding RNAs (lncRNAs) are more than 200 nucleotides in length and lack transcriptional ability. The biological function of lncRNAs in oral squamous cell carcinoma (OSCC) remains unclear. The aim of thi...

    Cheng-Mei Yang, Tsung-Han Wang, Hung-Chih Chen, Sung-Chou Li, Ming-Chien Lee, Huei-Han Liou, Pei-Feng Liu, Yu-Kai Tseng, Yow-Ling Shiue, Luo-Ping Ger and Kuo-Wang Tsai

    Clinical Epigenetics 2016 8:129

    Published on: 26 November 2016

  10. Research

    Smoking-associated DNA methylation markers predict lung cancer incidence

    Newly established blood DNA methylation markers that are strongly associated with smoking might open new avenues for lung cancer (LC) screening. We aimed to assess the performance of the top hits from previous...

    Yan Zhang, Magdeldin Elgizouli, Ben Schöttker, Bernd Holleczek, Alexandra Nieters and Hermann Brenner

    Clinical Epigenetics 2016 8:127

    Published on: 25 November 2016

  11. Short report

    Assessment of global DNA methylation in the first trimester fetal tissues exposed to maternal cigarette smoking

    Maternal cigarette smoking during pregnancy increases the risk of negative health consequences for the exposed child. Epigenetic mechanisms constitute a likely link between the prenatal exposure to maternal ci...

    Svetlana Fa, Trine Vilsbøll Larsen, Katrine Bilde, Tina F. Daugaard, Emil H. Ernst, Rasmus H. Olesen, Linn S. Mamsen, Erik Ernst, Agnete Larsen and Anders L. Nielsen

    Clinical Epigenetics 2016 8:128

    Published on: 25 November 2016

  12. Research

    Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes

    A role of proinflammation has been implicated in the pathogenesis of diabetes, but the up-stream regulatory signals and molecular signatures are poorly understood. While histone modifications such as changes i...

    Chandrakumar Sathishkumar, Paramasivam Prabu, Mahalingam Balakumar, Raji Lenin, Durai Prabhu, Ranjith Mohan Anjana, Viswanathan Mohan and Muthuswamy Balasubramanyam

    Clinical Epigenetics 2016 8:125

    Published on: 24 November 2016

  13. Research

    Increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates cyclic adenosine 5'-monophosphate response element modulator alpha in systemic lupus erythematosus

    Up-regulated cyclic adenosine 5'-monophosphate response element modulator α (CREMα) which can inhibit IL-2 and induce IL-17A in T cells plays a critical role in the pathogenesis of systemic lupus erythematosus...

    Qing Zhang, Shu Ding, Huilin Zhang, Hai Long, Haijing Wu, Ming Zhao, Vera Chan, Chak-Sing Lau and Qianjin Lu

    Clinical Epigenetics 2016 8:126

    Published on: 24 November 2016

  14. Research

    Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects

    Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, m...

    Shaza B. Zaghlool, Mashael Al-Shafai, Wadha A. Al Muftah, Pankaj Kumar, Christian Gieger, Melanie Waldenberger, Mario Falchi and Karsten Suhre

    Clinical Epigenetics 2016 8:124

    Published on: 22 November 2016

  15. Review

    Genome-wide epigenomic profiling for biomarker discovery

    A myriad of diseases is caused or characterized by alteration of epigenetic patterns, including changes in DNA methylation, post-translational histone modifications, or chromatin structure. These changes of th...

    René A. M. Dirks, Hendrik G. Stunnenberg and Hendrik Marks

    Clinical Epigenetics 2016 8:122

    Published on: 21 November 2016

  16. Research

    cPAS-based sequencing on the BGISEQ-500 to explore small non-coding RNAs

    We present the first sequencing data using the combinatorial probe-anchor synthesis (cPAS)-based BGISEQ-500 sequencer. Applying cPAS, we investigated the repertoire of human small non-coding RNAs and compared it ...

    Tobias Fehlmann, Stefanie Reinheimer, Chunyu Geng, Xiaoshan Su, Snezana Drmanac, Andrei Alexeev, Chunyan Zhang, Christina Backes, Nicole Ludwig, Martin Hart, Dan An, Zhenzhen Zhu, Chongjun Xu, Ao Chen, Ming Ni, Jian Liu…

    Clinical Epigenetics 2016 8:123

    Published on: 21 November 2016

  17. Erratum

    Erratum to: Donor age and C1orf132/MIR29B2C determine age-related methylation signature of blood after allogeneic hematopoietic stem cell transplantation

    Magdalena Spólnicka, Renata Zbieć Piekarska, Emilia Jaskuła, Grzegorz W. Basak, Renata Jacewicz, Agnieszka Pięta, Żanetta Makowska, Maciej Jedrzejczyk, Agnieszka Wierzbowska, Agnieszka Pluta, Tadeusz Robak, Jarosław Berent, Wojciech Branicki, Wiesław Jędrzejczak, Andrzej Lange and Rafał Płoski

    Clinical Epigenetics 2016 8:121

    Published on: 18 November 2016

    The original article was published in Clinical Epigenetics 2016 8:93

  18. Research

    Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood

    Both higher and lower fetal growth are associated with cardio-metabolic health later in life, suggesting that prenatal developmental programming determines long-term cardiovascular disease risk. Epigenetic mec...

    Golareh Agha, Hanine Hajj, Sheryl L. Rifas-Shiman, Allan C. Just, Marie-France Hivert, Heather H. Burris, Xihong Lin, Augusto A. Litonjua, Emily Oken, Dawn L. DeMeo, Matthew W. Gillman and Andrea A. Baccarelli

    Clinical Epigenetics 2016 8:118

    Published on: 16 November 2016

  19. Research

    Variations in DNA methylation of interferon gamma and programmed death 1 in allograft rejection after kidney transplantation

    The role of DNA methylation in the regulation of the anti-donor-directed immune response after organ transplantation is unknown. Here, we studied the methylation of two mediators of the immune response: the pr...

    Karin Boer, L. Elly A. de Wit, Fleur S. Peters, Dennis A. Hesselink, Leo J. Hofland, Michiel G. H. Betjes, Caspar W. N. Looman and Carla C. Baan

    Clinical Epigenetics 2016 8:116

    Published on: 16 November 2016

  20. Research

    Cell-free DNA promoter hypermethylation in plasma as a diagnostic marker for pancreatic adenocarcinoma

    Pancreatic cancer has a 5-year survival rate of only 5–7%. Difficulties in detecting pancreatic cancer at early stages results in the high mortality and substantiates the need for additional diagnostic tools. ...

    Stine Dam Henriksen, Poul Henning Madsen, Anders Christian Larsen, Martin Berg Johansen, Asbjørn Mohr Drewes, Inge Søkilde Pedersen, Henrik Krarup and Ole Thorlacius-Ussing

    Clinical Epigenetics 2016 8:117

    Published on: 16 November 2016

  21. Research

    Effect of prenatal DHA supplementation on the infant epigenome: results from a randomized controlled trial

    Evidence is accumulating that nutritional exposures in utero can influence health outcomes in later life. Animal studies and human epidemiological studies have implicated epigenetic modifications as playing a ...

    Susan J. van Dijk, Jing Zhou, Timothy J. Peters, Michael Buckley, Brodie Sutcliffe, Yalchin Oytam, Robert A. Gibson, Andrew McPhee, Lisa N. Yelland, Maria Makrides, Peter L. Molloy and Beverly S. Muhlhausler

    Clinical Epigenetics 2016 8:114

    Published on: 4 November 2016

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