Nutritional and environmental epigenetics

Section information

Section edited by Carmen Marsit
Although epigenetic mechanisms are inherently stable through cell divisions, nutritional and environmental factors can shape the epigenetic landscape. This section aims to cover the breadth and depth of studies examining the impacts of nutritional factors and the environment, on epigenetic regulation.  Nutrition may encompass the specific effects of nutrients as well as more holistic evaluation of dietary and eating patterns, while environmental factors can be broadly interpreted to include the chemical environment, psychosocial and demographic factors, the metabolic environment, pharmaceuticals and drugs of abuse. Articles in this section may use animal model or human population approaches to vigorously identify how nutritional and environmental factors impact the full range of epigenetic mechanisms and the implication of those changes or that variation on phenotypic outcomes.

  1. Research

    Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization

    Asthma gene DNA methylation may underlie the effects of air pollution on airway inflammation. However, the temporality and individual susceptibility to environmental epigenetic regulation of asthma has not bee...

    Kyung Hwa Jung, Stephanie Lovinsky-Desir, Beizhan Yan, David Torrone, Jennifer Lawrence, Jacqueline R. Jezioro, Matthew Perzanowski, Frederica P. Perera, Steven N. Chillrud and Rachel L. Miller

    Clinical Epigenetics 2017 9:61

    Published on: 2 June 2017

  2. Research

    Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation

    Omega-3 polyunsaturated fatty acids (n-3 FAs) have several beneficial effects on cardiovascular (CV) disease risk factors. These effects on CV risk profile may be mediated by several factors, including epigene...

    Bénédicte L. Tremblay, Frédéric Guénard, Iwona Rudkowska, Simone Lemieux, Patrick Couture and Marie-Claude Vohl

    Clinical Epigenetics 2017 9:43

    Published on: 26 April 2017

  3. Research

    36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner

    Subjects born with low birth weight (LBW) display a more energy-conserving response to fasting compared with normal birth weight (NBW) subjects. However, the molecular mechanisms explaining these metabolic dif...

    Line Hjort, Sine W. Jørgensen, Linn Gillberg, Elin Hall, Charlotte Brøns, Jan Frystyk, Allan A. Vaag and Charlotte Ling

    Clinical Epigenetics 2017 9:40

    Published on: 21 April 2017

  4. Research

    Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk—an exploratory study

    Prenatal environmental conditions may influence disease risk in later life. We previously found a gene-environment interaction between the paraoxonase 1 (PON1) Q192R genotype and prenatal pesticide exposure leadi...

    Ken Declerck, Sylvie Remy, Christine Wohlfahrt-Veje, Katharina M. Main, Guy Van Camp, Greet Schoeters, Wim Vanden Berghe and Helle R. Andersen

    Clinical Epigenetics 2017 9:35

    Published on: 5 April 2017

  5. Research

    Associations of LEP, CRH, ICAM-1, and LINE-1 methylation, measured in saliva, with waist circumference, body mass index, and percent body fat in mid-childhood

    Genetics explains a small proportion of variance in body mass index at the population level. Epigenetics, commonly measured by gene methylation, holds promise for understanding obesity risk factors and mechani...

    Jocelyn Dunstan, Joseph P. Bressler, Timothy H. Moran, Jonathan S. Pollak, Annemarie G. Hirsch, Lisa Bailey-Davis, Thomas A. Glass and Brian S. Schwartz

    Clinical Epigenetics 2017 9:29

    Published on: 29 March 2017

  6. Research

    Epigenetic signatures of gestational diabetes mellitus on cord blood methylation

    Intrauterine exposure to gestational diabetes mellitus (GDM) confers a lifelong increased risk for metabolic and other complex disorders to the offspring. GDM-induced epigenetic modifications modulating gene r...

    Larissa Haertle, Nady El Hajj, Marcus Dittrich, Tobias Müller, Indrajit Nanda, Harald Lehnen and Thomas Haaf

    Clinical Epigenetics 2017 9:28

    Published on: 27 March 2017

  7. Research

    Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants

    Maternal nutrition during pregnancy and infant nutrition in the early postnatal period (lactation) are critically involved in the development and health of the newborn infant. The Maternal Nutrition and Offspr...

    Sara Pauwels, Manosij Ghosh, Radu Corneliu Duca, Bram Bekaert, Kathleen Freson, Inge Huybrechts, Sabine A. S. Langie, Gudrun Koppen, Roland Devlieger and Lode Godderis

    Clinical Epigenetics 2017 9:16

    Published on: 7 February 2017

  8. Short report

    Assessment of global DNA methylation in the first trimester fetal tissues exposed to maternal cigarette smoking

    Maternal cigarette smoking during pregnancy increases the risk of negative health consequences for the exposed child. Epigenetic mechanisms constitute a likely link between the prenatal exposure to maternal ci...

    Svetlana Fa, Trine Vilsbøll Larsen, Katrine Bilde, Tina F. Daugaard, Emil H. Ernst, Rasmus H. Olesen, Linn S. Mamsen, Erik Ernst, Agnete Larsen and Anders L. Nielsen

    Clinical Epigenetics 2016 8:128

    Published on: 25 November 2016

  9. Research

    Effect of prenatal DHA supplementation on the infant epigenome: results from a randomized controlled trial

    Evidence is accumulating that nutritional exposures in utero can influence health outcomes in later life. Animal studies and human epidemiological studies have implicated epigenetic modifications as playing a ...

    Susan J. van Dijk, Jing Zhou, Timothy J. Peters, Michael Buckley, Brodie Sutcliffe, Yalchin Oytam, Robert A. Gibson, Andrew McPhee, Lisa N. Yelland, Maria Makrides, Peter L. Molloy and Beverly S. Muhlhausler

    Clinical Epigenetics 2016 8:114

    Published on: 4 November 2016

  10. Research

    DNA methylation and smoking in Korean adults: epigenome-wide association study

    Exposure to cigarette smoking can increase the risk of cancers and cardiovascular and pulmonary diseases. However, the underlying mechanisms of how smoking contributes to disease risks are not completely under...

    Mi Kyeong Lee, Yoonki Hong, Sun-Young Kim, Stephanie J. London and Woo Jin Kim

    Clinical Epigenetics 2016 8:103

    Published on: 22 September 2016

  11. Short report

    Epigenetic features of FoxP3 in children with cow’s milk allergy

    DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs...

    Lorella Paparo, Rita Nocerino, Linda Cosenza, Rosita Aitoro, Valeria D’Argenio, Valentina Del Monaco, Carmen Di Scala, Antonio Amoroso, Margherita Di Costanzo, Francesco Salvatore and Roberto Berni Canani

    Clinical Epigenetics 2016 8:86

    Published on: 12 August 2016

  12. Research

    Tobacco smoking differently influences cell types of the innate and adaptive immune system—indications from CpG site methylation

    Tobacco smoke is worldwide one of the main preventable lifestyle inhalative pollutants causing severe adverse health effects. Epidemiological studies revealed association of tobacco smoking with epigenetic cha...

    Mario Bauer, Beate Fink, Loreen Thürmann, Markus Eszlinger, Gunda Herberth and Irina Lehmann

    Clinical Epigenetics 2016 8:83

    Published on: 3 August 2016

  13. Research

    DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13½ years: Project Ice Storm

    Prenatal maternal stress (PNMS) is an important programming factor of postnatal immunity. We tested here the hypothesis that DNA methylation of genes in the NF-κB signaling pathway in T cells mediates the effe...

    Lei Cao-Lei, Franz Veru, Guillaume Elgbeili, Moshe Szyf, David P. Laplante and Suzanne King

    Clinical Epigenetics 2016 8:54

    Published on: 12 May 2016

  14. Research

    Expression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in mice

    Maternal obesity impacts fetal growth and pregnancy outcomes. To counteract the deleterious effects of obesity on fertility and pregnancy issue, preconceptional weight loss is recommended to obese women. Wheth...

    Polina E. Panchenko, Sarah Voisin, Mélanie Jouin, Luc Jouneau, Audrey Prézelin, Simon Lecoutre, Christophe Breton, Hélène Jammes, Claudine Junien and Anne Gabory

    Clinical Epigenetics 2016 8:22

    Published on: 27 February 2016

  15. Research

    X chromosome-wide analysis identifies DNA methylation sites influenced by cigarette smoking

    Tobacco smoking is a major cause of chronic disease worldwide. Smoking may induce cellular and molecular changes including epigenetic modification, with both short-term and long-term modification patterns that...

    Daniella Klebaner, Yunfeng Huang, Qin Hui, Jacquelyn Y. Taylor, Jack Goldberg, Viola Vaccarino and Yan V. Sun

    Clinical Epigenetics 2016 8:20

    Published on: 24 February 2016

  16. Research

    Epigenetic associations of type 2 diabetes and BMI in an Arab population

    The prevalence of type 2 diabetes (T2D) and obesity has dramatically increased within a few generations, reaching epidemic levels. In addition to genetic risk factors, epigenetic mechanisms triggered by changi...

    Wadha A. Al Muftah, Mashael Al-Shafai, Shaza B. Zaghlool, Alessia Visconti, Pei-Chien Tsai, Pankaj Kumar, Tim Spector, Jordana Bell, Mario Falchi and Karsten Suhre

    Clinical Epigenetics 2016 8:13

    Published on: 28 January 2016

  17. Research

    Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains

    Inadequate maternal nutrition during early fetal development can create permanent alterations in the offspring, leading to poor health outcomes. While nutrients involved in one-carbon cycle metabolism are impo...

    Lauren E. McCullough, Erline E. Miller, Michelle A. Mendez, Amy P. Murtha, Susan K. Murphy and Cathrine Hoyo

    Clinical Epigenetics 2016 8:8

    Published on: 22 January 2016

  18. Research

    The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

    Folate and its synthetic form folic acid function as donor of one-carbon units and have been, together with other B-vitamins, implicated in programming of epigenetic processes such as DNA methylation during ea...

    Dieuwertje E. G. Kok, Rosalie A. M. Dhonukshe-Rutten, Carolien Lute, Sandra G. Heil, André G. Uitterlinden, Nathalie van der Velde, Joyce B. J. van Meurs, Natasja M. van Schoor, Guido J. E. J. Hooiveld, Lisette C. P. G. M. de Groot, Ellen Kampman and Wilma T. Steegenga

    Clinical Epigenetics 2015 7:121

    Published on: 14 November 2015

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