Cardiovascular epigenetics

Section information

Section edited by Xiaoling Wang 
The impact of epigenetics in cardiovascular disease is now emerging as an important player at different levels from etiology to therapeutics. This section publishes original epigenetic research and reviews in all cardiovascular medical specialties from both animal model and human studies. Research that links epigenetic regulation with cardiovascular risk factors, biomarkers and subclinical cardiovascular diseases will also be included in this section.

  1. Research

    Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study

    DNA methylation is a key epigenetic mechanism that is suggested to be associated with blood lipid levels. We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of trig...

    Kim V. E. Braun, Klodian Dhana, Paul S. de Vries, Trudy Voortman, Joyce B. J. van Meurs, Andre G. Uitterlinden, Albert Hofman, Frank B. Hu, Oscar H. Franco and Abbas Dehghan

    Clinical Epigenetics 2017 9:15

    Published on: 7 February 2017

  2. Short report

    DNA methylation at birth within the promoter of ANRIL predicts markers of cardiovascular risk at 9 years

    Antisense non-coding RNA in the INK4 locus (ANRIL) fixed genetic variants have consistently been linked with coronary heart disease (CHD) risk. We investigated relationships between perinatal ANRIL promoter DN...

    Robert Murray, Jennifer Bryant, Phil Titcombe, Sheila J. Barton, Hazel Inskip, Nicholas C. Harvey, Cyrus Cooper, Karen Lillycrop, Mark Hanson and Keith M. Godfrey

    Clinical Epigenetics 2016 8:90

    Published on: 2 September 2016

  3. Research

    The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation

    Gender, genetic makeup, and prior experience interact to determine physiological responses to an external perceived stressor. Here, we investigated the contribution of both genetic variants and promoter methyl...

    Ting Li-Tempel, Mauro F. Larra, Estelle Sandt, Sophie B. Mériaux, Andrea B. Schote, Hartmut Schächinger, Claude P. Muller and Jonathan D. Turner

    Clinical Epigenetics 2016 8:12

    Published on: 28 January 2016

  4. Research

    Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

    DNA methylation profiles are responsive to environmental stimuli and metabolic shifts. This makes DNA methylation a potential biomarker of environmental-related and lifestyle-driven diseases of adulthood. Ther...

    Simonetta Guarrera, Giovanni Fiorito, N. Charlotte Onland-Moret, Alessia Russo, Claudia Agnoli, Alessandra Allione, Cornelia Di Gaetano, Amalia Mattiello, Fulvio Ricceri, Paolo Chiodini, Silvia Polidoro, Graziella Frasca, Monique W. M. Verschuren, Jolanda M. A. Boer, Licia Iacoviello, Yvonne T. van der Schouw…

    Clinical Epigenetics 2015 7:133

    Published on: 24 December 2015