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Section edited by Lucia Altucci, James Davie, Eamonn Maher, Adele Murrell, Trygve O Tollefsbol and Bryan Turner
This section welcomes articles from any discipline of clinical epigenetics not covered by the other journal sections.

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  1. Research

    Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD

    Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription ...

    J. Song, I. H. Heijink, L. E. M. Kistemaker, M. Reinders-Luinge, W. Kooistra, J. A. Noordhoek, R. Gosens, C. A. Brandsma, W. Timens, P. S. Hiemstra, M. G. Rots and M. N. Hylkema

    Clinical Epigenetics 2017 9:42

    Published on: 24 April 2017

  2. Research

    DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD

    Epigenetics changes have been shown to be affected by cigarette smoking. Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbati...

    Isaac K. Sundar, Qiangzong Yin, Brian S. Baier, Li Yan, Witold Mazur, Dongmei Li, Martha Susiarjo and Irfan Rahman

    Clinical Epigenetics 2017 9:38

    Published on: 14 April 2017

  3. Research

    DNA methylation at modifier genes of lung disease severity is altered in cystic fibrosis

    Lung disease progression is variable among cystic fibrosis (CF) patients and depends on DNA mutations in the CFTR gene, polymorphic variations in disease modifier genes, and environmental exposure. The contributi...

    Milena Magalhães, Isabelle Rivals, Mireille Claustres, Jessica Varilh, Mélodie Thomasset, Anne Bergougnoux, Laurent Mely, Sylvie Leroy, Harriet Corvol, Loïc Guillot, Marlène Murris, Emmanuelle Beyne, Davide Caimmi, Isabelle Vachier, Raphaël Chiron and Albertina De Sario

    Clinical Epigenetics 2017 9:19

    Published on: 14 February 2017

  4. Short report

    The epigenomic basis of common diseases

    A report of the 6th Epigenomics of Common Diseases Conference held at the Wellcome Genome Campus in Hinxton, Cambridge, UK, on 1–4 November 2016.

    Euan J. Rodger and Aniruddha Chatterjee

    Clinical Epigenetics 2017 9:5

    Published on: 19 January 2017

  5. Research

    Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects

    Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, m...

    Shaza B. Zaghlool, Mashael Al-Shafai, Wadha A. Al Muftah, Pankaj Kumar, Christian Gieger, Melanie Waldenberger, Mario Falchi and Karsten Suhre

    Clinical Epigenetics 2016 8:124

    Published on: 22 November 2016

  6. Research

    cPAS-based sequencing on the BGISEQ-500 to explore small non-coding RNAs

    We present the first sequencing data using the combinatorial probe-anchor synthesis (cPAS)-based BGISEQ-500 sequencer. Applying cPAS, we investigated the repertoire of human small non-coding RNAs and compared it ...

    Tobias Fehlmann, Stefanie Reinheimer, Chunyu Geng, Xiaoshan Su, Snezana Drmanac, Andrei Alexeev, Chunyan Zhang, Christina Backes, Nicole Ludwig, Martin Hart, Dan An, Zhenzhen Zhu, Chongjun Xu, Ao Chen, Ming Ni, Jian Liu…

    Clinical Epigenetics 2016 8:123

    Published on: 21 November 2016

  7. Research

    PITX3 promoter methylation is a prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients after radical prostatectomy

    Molecular biomarkers that might help to distinguish between more aggressive and clinically insignificant prostate cancers (PCa) are still urgently needed. Aberrant DNA methylation as a common molecular alterat...

    Emily Eva Holmes, Diane Goltz, Verena Sailer, Maria Jung, Sebastian Meller, Barbara Uhl, Jörn Dietrich, Magda Röhler, Jörg Ellinger, Glen Kristiansen and Dimo Dietrich

    Clinical Epigenetics 2016 8:104

    Published on: 26 September 2016

  8. Review

    The emerging role of lysine methyltransferase SETD8 in human diseases

    SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase (KMT) that monomethylates lysine 20 of histone H4 (H4K20) in vivo. Lysine residues of non-histone proteins including proliferating cell nucle...

    Ciro Milite, Alessandra Feoli, Monica Viviano, Donatella Rescigno, Agostino Cianciulli, Amodio Luca Balzano, Antonello Mai, Sabrina Castellano and Gianluca Sbardella

    Clinical Epigenetics 2016 8:102

    Published on: 22 September 2016

  9. Methodology

    MSP-HTPrimer: a high-throughput primer design tool to improve assay design for DNA methylation analysis in epigenetics

    Bisulfite (BS) conversion-based and methylation-sensitive restriction enzyme (MSRE)-based PCR methods have been the most commonly used techniques for locus-specific DNA methylation analysis. However, both meth...

    Ram Vinay Pandey, Walter Pulverer, Rainer Kallmeyer, Gabriel Beikircher, Stephan Pabinger, Albert Kriegner and Andreas Weinhäusel

    Clinical Epigenetics 2016 8:101

    Published on: 21 September 2016

  10. Research

    SEPT9 and SHOX2 DNA methylation status and its utility in the diagnosis of colonic adenomas and colorectal adenocarcinomas

    Colorectal cancer (CRC) appear to arise from precursor lesions in a well-characterized adenoma-carcinoma sequence. Significant efforts have been invested to develop biomarkers that identify early adenocarcinom...

    Alexander Semaan, Anne van Ellen, Sebastian Meller, Dominik Bergheim, Vittorio Branchi, Philipp Lingohr, Diane Goltz, Jörg C. Kalff, Glen Kristiansen, Hanno Matthaei, Dimitrios Pantelis and Dimo Dietrich

    Clinical Epigenetics 2016 8:100

    Published on: 20 September 2016

  11. Review

    DNA methylation: conducting the orchestra from exposure to phenotype?

    DNA methylation, through 5-methyl- and 5-hydroxymethylcytosine (5mC and 5hmC), is considered to be one of the principal interfaces between the genome and our environment, and it helps explain phenotypic variat...

    Fleur A. D. Leenen, Claude P. Muller and Jonathan D. Turner

    Clinical Epigenetics 2016 8:92

    Published on: 6 September 2016

  12. Short report

    Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy

    DNA methylation is an essential epigenetic mark, controlled by DNA methyltransferase (DNMT) proteins, which regulates chromatin structure and gene expression throughout the genome. In this study, we describe a...

    Kristin D. Kernohan, Laila Cigana Schenkel, Lijia Huang, Amanda Smith, Guillaume Pare, Peter Ainsworth, Kym M. Boycott, Jodi Warman-Chardon and Bekim Sadikovic

    Clinical Epigenetics 2016 8:91

    Published on: 5 September 2016

  13. Research

    Genome-wide DNA methylation profiling with MeDIP-seq using archived dried blood spots

    In utero and early-life experienced environmental exposures are suggested to play an important role in many multifactorial diseases potentially mediated through lasting effects on the epigenome. As the epigeno...

    Nicklas H. Staunstrup, Anna Starnawska, Mette Nyegaard, Lene Christiansen, Anders L. Nielsen, Anders Børglum and Ole Mors

    Clinical Epigenetics 2016 8:81

    Published on: 26 July 2016

  14. Research

    DNA methylation profiling identifies novel markers of progression in hepatitis B-related chronic liver disease

    Chronic hepatitis B infection is characterized by hepatic immune and inflammatory response with considerable variation in the rates of progression to cirrhosis. Genetic variants and environmental cues influenc...

    Müjdat Zeybel, Sezgin Vatansever, Timothy Hardy, Ayşegül Akder Sarı, Fulya Cakalağaoğlu, Arzu Avcı, Gemma Louise Zeybel, Serçin Karahüseyinoğlu, Matthew Bashton, John C. Mathers, Belkıs Ünsal and Jelena Mann

    Clinical Epigenetics 2016 8:48

    Published on: 5 May 2016

  15. Research

    Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation

    Genomic imprinting evolved in a common ancestor to marsupials and eutherian mammals and ensured the transcription of developmentally important genes from defined parental alleles. The regulation of imprinted g...

    Florian Bohne, David Langer, Ursula Martiné, Claudia S. Eider, Regina Cencic, Matthias Begemann, Miriam Elbracht, Luzie Bülow, Thomas Eggermann, Ulrich Zechner, Jerry Pelletier, Bernhard Ulrich Zabel, Thorsten Enklaar and Dirk Prawitt

    Clinical Epigenetics 2016 8:47

    Published on: 4 May 2016

  16. Review

    Establishing an analytic pipeline for genome-wide DNA methylation

    The need for research investigating DNA methylation (DNAm) in clinical studies has increased, leading to the evolution of new analytic methods to improve accuracy and reproducibility of the interpretation of r...

    Michelle L. Wright, Mikhail G. Dozmorov, Aaron R. Wolen, Colleen Jackson-Cook, Angela R. Starkweather, Debra E. Lyon and Timothy P. York

    Clinical Epigenetics 2016 8:45

    Published on: 27 April 2016

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