Aging, development, imprinting and reproductive epigenetics

Section information

Section edited by Monika Puzianowska-Kuznicka, Akihiro Umezawa and Wolfgang Wagner

Developmental processes are governed by epigenetics and there is a growing evidence that this applies also to aging of the organism. Furthermore, genomic imprinting, the epigenetic phenomenon reducing expression of certain genes to either maternal or paternal alleles, as well as epigenetics in reproductive medicine are of increasing relevance. Likewise, epigenetic factors in prenatal and postnatal development as well as later in life significantly contribute to the rate and phenotype of aging. This section covers the full breadth of these interdisciplinary research areas. It aims for outstanding original contributions, which provide novel and sound insight into the underlying mechanisms of development and aging. Description of biomarkers or resource paper can also be considered if they significantly advance the field. Epigenetic raw data should be deposited in public data repositories. Studies on non-human model systems can also be considered if they provide insight into relevant epigenetic processes.

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  1. Short report

    A methylation PCR method determines FMR1 activation ratios and differentiates premutation allele mosaicism in carrier siblings

    Epigenetic modifications of the fragile X mental retardation 1 (FMR1) gene locus may impact the risk for reproductive and neurological disorders associated with expanded trinucleotide repeats and methylation stat...

    Andrew G. Hadd, Stela Filipovic-Sadic, Lili Zhou, Arianna Williams, Gary J. Latham, Elizabeth Berry-Kravis and Deborah A. Hall

    Clinical Epigenetics 2016 8:130

    Published on: 1 December 2016

  2. Research

    Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood

    Both higher and lower fetal growth are associated with cardio-metabolic health later in life, suggesting that prenatal developmental programming determines long-term cardiovascular disease risk. Epigenetic mec...

    Golareh Agha, Hanine Hajj, Sheryl L. Rifas-Shiman, Allan C. Just, Marie-France Hivert, Heather H. Burris, Xihong Lin, Augusto A. Litonjua, Emily Oken, Dawn L. DeMeo, Matthew W. Gillman and Andrea A. Baccarelli

    Clinical Epigenetics 2016 8:118

    Published on: 16 November 2016

  3. Short report

    Narrowing the FOXF1 distant enhancer region on 16q24.1 critical for ACDMPV

    Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare lethal lung developmental disorder caused by heterozygous point mutations or genomic deletions involving FOXF1 or its 60-kb tis...

    Przemyslaw Szafranski, Carmen Herrera, Lori A. Proe, Brittany Coffman, Debra L. Kearney, Edwina Popek and Paweł Stankiewicz

    Clinical Epigenetics 2016 8:112

    Published on: 3 November 2016

  4. Research

    Intra-individual changes in DNA methylation not mediated by cell-type composition are correlated with aging during childhood

    Several studies have reported age-associated changes in DNA methylation in the first few years of life and in adult populations, but the extent of such changes during childhood is less well studied. The goals ...

    Kristina Gervin, Bettina Kulle Andreassen, Hanne Sagsveen Hjorthaug, Karin C. Lødrup Carlsen, Kai-Håkon Carlsen, Dag Erik Undlien, Robert Lyle and Monica Cheng Munthe-Kaas

    Clinical Epigenetics 2016 8:110

    Published on: 21 October 2016

  5. Letter to the Editor

    Donor age and C1orf132/MIR29B2C determine age-related methylation signature of blood after allogeneic hematopoietic stem cell transplantation

    Our recent study demonstrated that DNA methylation status in a set of CpGs located in ELOVL2, C1orf132, TRIM59, KLF14, and FHL2 can accurately predict calendar age in blood. In the present work, we used these mar...

    Magdalena Spólnicka, Renata Zbieć Piekarska, Emilia Jaskuła, Grzegorz W. Basak, Renata Jacewicz, Agnieszka Pięta, Żanetta Makowska, Maciej Jedrzejczyk, Agnieszka Wierzbowska, Agnieszka Pluta, Tadeusz Robak, Jarosław Berent, Wojciech Branicki, Wiesław Jędrzejczak, Andrzej Lange and Rafał Płoski

    Clinical Epigenetics 2016 8:93

    Published on: 6 September 2016

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:121

  6. Research

    Genome-wide placental DNA methylation analysis of severely growth-discordant monochorionic twins reveals novel epigenetic targets for intrauterine growth restriction

    Intrauterine growth restriction (IUGR), which refers to reduced fetal growth in the context of placental insufficiency, is etiologically heterogeneous. IUGR is associated not only with perinatal morbidity and ...

    Maian Roifman, Sanaa Choufani, Andrei L. Turinsky, Sascha Drewlo, Sarah Keating, Michael Brudno, John Kingdom and Rosanna Weksberg

    Clinical Epigenetics 2016 8:70

    Published on: 21 June 2016

  7. Short report

    Two maternal duplications involving the CDKN1C gene are associated with contrasting growth phenotypes

    The overgrowth-associated Beckwith-Wiedemann syndrome (BWS) and the undergrowth-associated Silver-Russell syndrome (SRS) are characterized by heterogeneous molecular defects affecting a large imprinted gene cl...

    Susanne Eriksen Boonen, Andrea Freschi, Rikke Christensen, Federica Maria Valente, Dorte Launholt Lildballe, Lucia Perone, Orazio Palumbo, Massimo Carella, Niels Uldbjerg, Angela Sparago, Andrea Riccio and Flavia Cerrato

    Clinical Epigenetics 2016 8:69

    Published on: 16 June 2016

  8. Research

    Amnion as a surrogate tissue reporter of the effects of maternal preeclampsia on the fetus

    Preeclampsia, traditionally characterized by high blood pressure and proteinuria, is a common pregnancy complication, which affects 2–8 % of all pregnancies. Although children born to women with preeclampsia h...

    Masako Suzuki, Ryo Maekawa, Nicole E. Patterson, David M. Reynolds, Brent R. Calder, Sandra E. Reznik, Hye J. Heo, Francine Hughes Einstein and John M. Greally

    Clinical Epigenetics 2016 8:67

    Published on: 10 June 2016

  9. Research

    A multi-method approach to the molecular diagnosis of overt and borderline 11p15.5 defects underlying Silver–Russell and Beckwith–Wiedemann syndromes

    Multiple (epi)genetic defects affecting the expression of the imprinted genes within the 11p15.5 chromosomal region underlie Silver–Russell (SRS) and Beckwith–Wiedemann (BWS) syndromes. The molecular diagnosis...

    Silvia Russo, Luciano Calzari, Alessandro Mussa, Ester Mainini, Matteo Cassina, Stefania Di Candia, Maurizio Clementi, Sara Guzzetti, Silvia Tabano, Monica Miozzo, Silvia Sirchia, Palma Finelli, Paolo Prontera, Silvia Maitz, Giovanni Sorge, Annalisa Calcagno…

    Clinical Epigenetics 2016 8:23

    Published on: 1 March 2016

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:40

  10. Research

    Genome-wide DNA methylation analysis of pseudohypoparathyroidism patients with GNAS imprinting defects

    Pseudohypoparathyroidism (PHP) is caused by (epi)genetic defects in the imprinted GNAS cluster. Current classification of PHP patients is hampered by clinical and molecular diagnostic overlaps. The European Conso...

    Anne Rochtus, Alejandro Martin-Trujillo, Benedetta Izzi, Francesca Elli, Intza Garin, Agnes Linglart, Giovanna Mantovani, Guiomar Perez de Nanclares, Suzanne Thiele, Brigitte Decallonne, Chris Van Geet, David Monk and Kathleen Freson

    Clinical Epigenetics 2016 8:10

    Published on: 26 January 2016

  11. Review

    Imprinting disorders: a group of congenital disorders with overlapping patterns of molecular changes affecting imprinted loci

    Congenital imprinting disorders (IDs) are characterised by molecular changes affecting imprinted chromosomal regions and genes, i.e. genes that are expressed in a parent-of-origin specific manner. Recent years...

    Thomas Eggermann, Guiomar Perez de Nanclares, Eamonn R. Maher, I. Karen Temple, Zeynep Tümer, David Monk, Deborah J. G. Mackay, Karen Grønskov, Andrea Riccio, Agnès Linglart and Irène Netchine

    Clinical Epigenetics 2015 7:123

    Published on: 14 November 2015

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:27

  12. Review

    Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health

    The correlation between epigenetics and human reproduction represents a very interesting field of study, mainly due to the possible transgenerational effects related to epigenetic modifications of male and fem...

    Liborio Stuppia, Marica Franzago, Patrizia Ballerini, Valentina Gatta and Ivana Antonucci

    Clinical Epigenetics 2015 7:120

    Published on: 11 November 2015

  13. Research

    High cortisol in 5-year-old children causes loss of DNA methylation in SINE retrotransposons: a possible role for ZNF263 in stress-related diseases

    Childhood stress leads to increased risk of many adult diseases, such as major depression and cardiovascular disease. Studies show that adults with experienced childhood stress have specific epigenetic changes...

    Daniel Nätt, Ingela Johansson, Tomas Faresjö, Johnny Ludvigsson and Annika Thorsell

    Clinical Epigenetics 2015 7:91

    Published on: 4 September 2015

  14. Short report

    Exploration of hydroxymethylation in Kagami-Ogata syndrome caused by hypermethylation of imprinting control regions

    5-Hydroxymethylcytosine (5hmC), converted from 5-methylcytosine (5mC) by ten-eleven translocation (Tet) enzymes, has recently drawn attention as the “sixth base” of DNA since it is considered an intermediate o...

    Keiko Matsubara, Masayo Kagami, Kazuhiko Nakabayashi, Kenichiro Hata, Maki Fukami, Tsutomu Ogata and Kazuki Yamazawa

    Clinical Epigenetics 2015 7:90

    Published on: 28 August 2015

  15. Review

    The placenta: phenotypic and epigenetic modifications induced by Assisted Reproductive Technologies throughout pregnancy

    Today, there is growing interest in the potential epigenetic risk related to assisted reproductive technologies (ART). Much evidence in the literature supports the hypothesis that adverse pregnancy outcomes li...

    Cécile Choux, Virginie Carmignac, Céline Bruno, Paul Sagot, Daniel Vaiman and Patricia Fauque

    Clinical Epigenetics 2015 7:87

    Published on: 21 August 2015

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