Type of leukemia | Dose-schedule | Duration infusion | Estimated plasma concentration | Estimated AUC (μM × hour) | Response %ORR (%CR) | References |
---|---|---|---|---|---|---|
AMLa | ind: 135 mg/m2main:20 mg/m2 | 1 to 72 hours | 0.12 to 1.25 μM | 0.12 to 90 | 26 | [143] |
AML | 20 mg/m2 | 1 hour | 1.25 μM | 1.25 | 25 (24) | [110] |
AML | 20 mg/m2 | 1 hour | 1.25 μM | 1.25 | 64 (47) | [144] |
CMML | 15 mg/m2 | 3 to 4 hours | 0.24 to 0.31 μM | 0.72 to 1.24 | 25(11) | |
AML | 20 mg/m2 | 1 hour | 1.25 μM | 1.25 | 67 (26) | [147] |
CML | 50 to 100 mg/m2 | 6 hour | 0.52 to 1.0 μM | 3.12 to 6.0 | B28(10),A55(23),C63(13) | [148] |
CML | 50 to 100 mg/m2 | 6 hours | 0.52 to 1.0 μM | 3.12 to 6.0 | 53 (0) | |
CML | 50 to 100 mg/m2 | 6 hours | 0,52 to 1,0 μM | 3.12 to 6.0 | 84 (10) | |
AMLb | 90 mg/m2 | 4 hours | 1.41 μM | 5.64 | 100 (100) | [149] |
AMLc | 125 to 250 mg/m2 | 6 hours | 1.3 to 2.6 μM | 7.8 to 15.6 | 44 (44) | [150] |
AMLd | 125 to 250 mg/m2 | 6 hours | 1.3 to 2.6 μM | 7.8 to 15.6 | 41 (41) | [151] |
AMLd | 125 to 250 mg/m2 | 6 hours | 1.3 to 2.6 μM | 7.8 to 15.6 | 82(73) | [137] |
AML | 250 to 500 mg/m2 | 6 hours | 2.61 to 5.2 μM | 15.66 to 31.2 | 20 (0) | [137] |
AML | 270 to 360 mg/ m2/day t.i.d. | 4 hours | 4.2 to 5.6 μM | 16.8 to 22.4 | 40 (30) | [109] |
AML, ALL, CML | 300 to 500 mg/m2/day c. i.v. | 24 to 120 hours | 0.16 to 1.3 μM | 3.84 to 156.0 | 26 (4) | [108] |
AML, ALL | 37 to 80 mg/kg c.i.v. | 36 to 60 hours | 1.4 to 5.15 μM | 50.4 to 309.0 | 37 (22) | [97] |
AML, ALL | 0.75 to 80 mg/kg conti.i.v. | 12 to 44 hours | 0.04 to 15 μM | 9.0 to 660.0 | 14 (9) | [7] |