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Table 2 DNA methylation scores before and after dexamethasone 4 mg/day for 4 days

From: Evidence for transcript-specific epigenetic regulation of glucocorticoid-stimulated skeletal muscle 11β-hydroxysteroid dehydrogenase-1 activity in type 2 diabetes

Methylation site

Before dexamethasone (%)

After dexamethasone (%)

P value

P1 promoter CpG

32 (29 to 35)

30 (28 to 33)

0.026

P2 promoter (CpG mean)

42 (37 to 43)

38 (36 to 41)

0.093

  (P2_CpG 2)

22 (16 to 24)

18 (17 to 22)

0.072

  (P2 _CpG 3)

41 (33 to 44)

37 (35 to 42)

0.409

  (P2 _CpG 4)

63 (58 to 66)

59 (56 to 62)

0.065

  1. Data presented as median (25th to 75th percentile). Methylation scores (approximating % of alleles with cytosine methylation at specific CpG sites within a tissue sample) were obtained from the Mass Spec output using EpiTYPER v1.0.5 software (Sequenom Inc, San Diego, CA, USA). Only a single CpG site was present in the P1 promoter region tested, whereas three sites in close proximity were assessed in P2.
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Clinical Epigenetics

ISSN: 1868-7083

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